Protein Info for Rru_A3431 in Rhodospirillum rubrum S1H

Annotation: Folylpolyglutamate synthetase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01499: bifunctional protein FolC
  • amino acids 23 to 427 (405 residues), 365.9 bits, E=1.8e-113
• PF02875: Mur_ligase_C
  • amino acids 303 to 419 (117 residues), 29.7 bits, E=1e-10

Best Hits

KEGG orthology group: K11754, dihydrofolate synthase / folylpolyglutamate synthase [EC: 6.3.2.12 6.3.2.17] (inferred from 100% identity to rru:Rru_A3431)

Predicted SEED Role

"Dihydrofolate synthase (EC 6.3.2.12) @ Folylpolyglutamate synthase (EC 6.3.2.17)" (EC 6.3.2.12, EC 6.3.2.17)

MetaCyc Pathways

• superpathway of tetrahydrofolate biosynthesis and salvage (10/12 steps found)
• tetrahydrofolate biosynthesis I (3/3 steps found)
• superpathway of tetrahydrofolate biosynthesis (8/10 steps found)
• folate polyglutamylation (4/5 steps found)
• tetrahydrofolate biosynthesis II (2/3 steps found)
• superpathway of chorismate metabolism (37/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.12 or 6.3.2.17

Sequence Analysis Tools

See Q2RNS0 at UniProt or InterPro

Protein Sequence (435 amino acids)

>Rru_A3431 Folylpolyglutamate synthetase (NCBI) (Rhodospirillum rubrum S1H)
MNAPDGVLARLMGLHPKVIDLSLGRVERLLAALGHPERALPPVIHVAGTNGKGSVVATCR
ALLEAAGYRVHVYTSPHLVRFGERIRLAGTLIADEALRRLLEEVESANAKAPITFFEVTT
AAAFLAFSRSPADVTLLEVGLGGRLDATNVIADPAVCAVTPIDLDHQQYLGSTLTAIAGE
KAGILKAGAPAVIAPQPPEAAQTLAARATAVGAPTLWAGRDWSWERTTTGWRFAGLDLPL
PVLAGPHQLGNAAQALAVIDALEARTGLRVEGVARARGLRAVDWPARLQRLDSGPLVERL
APGTTLWLDGGHNPHAGRALAAALGDDASGPLDVICGMLDTKDAGGFLGALAPLVRRLRC
VAVPDGQTGAGLAPDALAGHARAAGIADARSCASVAEALTDLGAGTTPPPAARILICGSL
YLAGTVLAENGTPPR