Protein Info for Rru_A3381 in Rhodospirillum rubrum S1H

Annotation: Cobyric acid synthase CobQ (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 496 PF13500: AAA_26" amino acids 13 to 239 (227 residues), 50.3 bits, see alignment E=4.4e-17 PF01656: CbiA" amino acids 15 to 247 (233 residues), 78.2 bits, see alignment E=7.9e-26 TIGR00313: cobyric acid synthase CobQ" amino acids 15 to 488 (474 residues), 437.4 bits, see alignment E=3.6e-135 PF07685: GATase_3" amino acids 267 to 447 (181 residues), 171.2 bits, see alignment E=3.1e-54

Best Hits

Swiss-Prot: 62% identical to COBQ_RHOS4: Cobyric acid synthase (cobQ) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to rru:Rru_A3381)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.10

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RNX0 at UniProt or InterPro

Protein Sequence (496 amino acids)

>Rru_A3381 Cobyric acid synthase CobQ (NCBI) (Rhodospirillum rubrum S1H)
MSATGPSPHHRARALMIQGTGSDVGKSLLVSGLARALTRRGLRVAPFKAQNMSNNAAVTA
DGGEIGRAQALQARACGLVPSVDMNPVLLKPQSETGSQLIVQGRVAGTVMAGRYRAMTAT
LMPTVLESFARLRAAADIVLVEGAGSPAEVNLRAGDIANMGFAEAADVPVVIVGDIDRGG
VIAALVGTHVLLPEAERRRIAGFLINKFRGDVGLFEPALAVIEGHTGWAPLGVIPWFPRA
SALPAEDAQSLESRPAAAARAGDGRLRIVVPRLSRIANFDDFDPLIAEPDVDLRFIGAGE
ALPGDADLVILPGSKATLADLAFLRAQGWDGDLLGHHRRGGRILGLCAGYQMLGRRVADP
QGVEGPAEERPGLGFLDVDTVMGGEKTLTAVRFRDHLWGAEGWGYEMHVGRTQGPDTRTP
WLHDGSARSADGRVLGAYVHGLFASDAFRRAFLGWLRPGRTAGIAYDDTVEATLDALADH
LERHVALDRLLALAAP