Protein Info for Rru_A3258 in Rhodospirillum rubrum S1H
Annotation: Ribonucleotide reductase large subunit (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00525, ribonucleoside-diphosphate reductase alpha chain [EC: 1.17.4.1] (inferred from 100% identity to rru:Rru_A3258)Predicted SEED Role
"Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)" in subsystem Ribonucleotide reduction (EC 1.17.4.1)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
- superpathway of purine nucleotide salvage (13/14 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis III (9/9 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis I (8/9 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (11/14 steps found)
- adenosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
- guanosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
- adenosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
- guanosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis IV (5/7 steps found)
- pyrimidine deoxyribonucleotides biosynthesis from CTP (5/8 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.17.4.1
Use Curated BLAST to search for 1.17.4.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RP92 at UniProt or InterPro
Protein Sequence (786 amino acids)
>Rru_A3258 Ribonucleotide reductase large subunit (NCBI) (Rhodospirillum rubrum S1H) MDRQPIVESIWREKYRLVDPDGSSLEQGPEDSFARVCRGIYARDPRRAVHEPLALEAMKA LEWCPGGRIHAGAGTDRRVTLINCFVNMIVPDRMDGIMEALTRAALTMQQGGGIGTDFST LRPRGAKVRRTGSVSSGPLSFMEIWHAMCGTIMSGGARRGAMMGTMICDHPDLPAFITAK AQAGRLTNFNVSVLVTDAFMRAVDEDATWDLGFSVPPADPARLVAVTERNGEPWYVYERL SARALWEKIIRTTYDHAEPGVIFIDRVNERNNLAYCETISCTNPCGEQPLPPNGDCNLGC VNLAVLVRDPFTPQARFDDARLAEVAAIGVRFLDNVLDVSNFPVEDQAKEAQAKRRLGLG IMGLGNALQMLGLRYGSPAAIAETRRIMALLRDAAYRASAELAGERGPFPLYDRDQLLAR PFIQELPDDLRAKIAEQGLRNGVMLTIAPTGTTAIYYNNVSSGLEPTFGWRYFRKVLRPD GGHDEFAVIDAGFESWCRTRGLDPATAPLTGLPDSMVTALELSVEDHLRMQAACQEFIDA SISKTINCPADMSYDSFAAVYKLAYEMGCKGCTTYRPSGTRGSVLSLDATTPAAAPVQKA PAPRTPAPPMRPEFLEGRTYKLRWPLSDENFYVTINDVRDEAGGRRPFEVFIASRSAEHA ELLSALTVTLSAVMRRTDNPAFLVEDLEQVRGAQGVWVKGRFVNGVVALVASVMRRHLAD LGLMDQIAERGAPEEETAPAAPSADASAPASAGAPIGDRCPACGQPTYFRQEGCSKCASC GHSTCS