Protein Info for Rru_A3213 in Rhodospirillum rubrum S1H

Annotation: PAS/PAC Sensor Signal Transduction Histidine Kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 778 PF12860: PAS_7" amino acids 160 to 273 (114 residues), 38.6 bits, see alignment E=4.4e-13 TIGR00229: PAS domain S-box protein" amino acids 277 to 404 (128 residues), 99.5 bits, see alignment E=7.7e-33 amino acids 405 to 532 (128 residues), 38.7 bits, see alignment E=5.1e-14 PF13188: PAS_8" amino acids 282 to 334 (53 residues), 30.1 bits, see alignment 1.3e-10 PF00989: PAS" amino acids 282 to 394 (113 residues), 61.2 bits, see alignment E=3.9e-20 PF08448: PAS_4" amino acids 290 to 398 (109 residues), 33.4 bits, see alignment E=1.9e-11 amino acids 425 to 528 (104 residues), 26.4 bits, see alignment E=2.9e-09 PF13426: PAS_9" amino acids 292 to 395 (104 residues), 59 bits, see alignment E=2e-19 PF08447: PAS_3" amino acids 432 to 519 (88 residues), 48 bits, see alignment E=4.9e-16 PF00512: HisKA" amino acids 546 to 615 (70 residues), 68.1 bits, see alignment E=2.2e-22 PF02518: HATPase_c" amino acids 662 to 773 (112 residues), 101.6 bits, see alignment E=1.4e-32

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A3213)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RPD7 at UniProt or InterPro

Protein Sequence (778 amino acids)

>Rru_A3213 PAS/PAC Sensor Signal Transduction Histidine Kinase (NCBI) (Rhodospirillum rubrum S1H)
MSAIDGPGLDSRLIDIFDHLDEGVALYGPDHRLIRFNRPFASLVETAGGRPAPGQRMVEI
LRDLVAPDTGEENRADSGPDDDGRGTEDDAAERLEGALLGTPTEIRLGRDRWGLVHGHRL
KDGALFCVLRDITASKAGAARIAESNRRIREAESRLERALESIDQGFYLCDASDTVVLRN
AKLAHLLPGLPPLEPGTTYGAMMAAACDNGAIPAATRHRTRWLSLCMARHHLPRGAWDFE
NGRGRWVRVSESLTPEGGRVGLLTDITETRKASEQVRQREQRLDGIMKTVVDGIVVIDEN
GIIESFNPAAERLFGYRAEEVVGASINRLIPGGESGRHDRSLRRYLQTGQAGIIGRGREE
LALRRDGSLLPVELAISELRLDDRRIFTGLVRDISARKEADRQLRENEERYALAIAGTHE
AIVDWDIDSDTITYSDRITAIVGLDPKDLDRSASWIALIHPDHRKDYLTRMDALLRGESS
FFSCDFRLAGRAGAEERWLRHRATALRRPDGQIYRLSGAVGDITDSRRGEDRLREAKEAA
EFANRAKSEFLTNMSHELRTPLNAIIGFSEVLHSEMFGPLGATQYLDYAASIRDSGRHLL
DVINDILDVSRIEAGRATLFPEPLDFAEIVASVHRLVNQRAEAAGVRLKITLDPALPPLL
GEARRLKQVLINLLGNAIKFTPAGGEIALSARGDEDKGQMVIEVSDSGIGMAPEDIPLAL
EPFRQIDGQLARRYEGTGLGLPLSKAFVELHGGTLRVDSTPGAGTRITVRLPAGAVES