Protein Info for Rru_A3109 in Rhodospirillum rubrum S1H

Annotation: Aspartate racemase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 29 to 408 (380 residues), 218.1 bits, E=4.4e-68
  • amino acids 1145 to 1495 (351 residues), 201.7 bits, E=4.1e-63
• PF00550: PP-binding
  • amino acids 591 to 656 (66 residues), 44.7 bits, see alignment (E = 3.3e-15)
  • amino acids 1658 to 1721 (64 residues), 23.2 bits, see alignment (E = 1.6e-08)
• PF00668: Condensation
  • amino acids 676 to 1018 (343 residues), 100.3 bits, E=2.8e-32
• PF13193: AMP-binding_C
  • amino acids 1552 to 1624 (73 residues), 37.7 bits, see alignment (E = 8.3e-13)
• PF00975: Thioesterase
  • amino acids 1786 to 1850 (65 residues), 39.3 bits, see alignment (E = 2.1e-13)

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A3109)

Predicted SEED Role

"Acetyl-coenzyme A synthetase (EC 6.2.1.1)" in subsystem Ketoisovalerate oxidoreductase or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 6.2.1.1)

MetaCyc Pathways

• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• superpathway of acetate utilization and formation (3/3 steps found)
• acetate and ATP formation from acetyl-CoA III (1/1 steps found)
• acetate conversion to acetyl-CoA (1/1 steps found)
• L-isoleucine biosynthesis V (2/3 steps found)
• ethanol degradation III (2/3 steps found)
• reductive glycine pathway of autotrophic CO₂ fixation (6/9 steps found)
• chitin deacetylation (1/4 steps found)
• adlupulone and adhumulone biosynthesis (1/6 steps found)
• colupulone and cohumulone biosynthesis (1/6 steps found)
• lupulone and humulone biosynthesis (1/6 steps found)
• cis-geranyl-CoA degradation (2/9 steps found)
• superpathway of bitter acids biosynthesis (3/18 steps found)

KEGG Metabolic Maps

• Glycolysis / Gluconeogenesis
• Propanoate metabolism
• Pyruvate metabolism
• Reductive carboxylate cycle (CO2 fixation)

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.1

Use Curated BLAST to search for 6.2.1.1

Sequence Analysis Tools

See Q2RPP1 at UniProt or InterPro

Protein Sequence (1981 amino acids)

>Rru_A3109 Aspartate racemase (NCBI) (Rhodospirillum rubrum S1H)
MPAPRWATMGAMLLDRAASLEESCAYRFLHDGGGGPEVRSYRALTSRALDIATFLLAKGC
AKRPVLILLPTGMAFVEALFGCFLAGAIAVPAPPPTGTRGLPRIRGILADCAPPLALVVE
PPQIDRLGGGDDAPLARTEWVRVADIPACATPDPSMVEAVAPGDIAVLQYTSGSTGTPKG
VVISHRNALINLAQQKSGMRAPDGARLVSWLPVHHDMGLFGNILITVAVGGELSFMAPSS
FLQKPIRWVQAISDYRGQASGGPDFGFDLCARRAQPADLAALDLSSWTTAYSGAEPVRAA
TLERFARVFAASGFRCEALRPCYGLAEATLIVSVQAVTQSLDVRRYDRQSLFAGIARQSD
DGEALTSCGPAVEGMEIAIVDAATSQPLPDNRVGEIWLSGPNLAEGYWNQPQMTAKRFGA
RLAGRGDRWLRSGDVGFLDRGQLFVVGRADDMIILRGRNIPPDDIENAALVSPIQVAGSA
VALAAPDEGGVILVQEVARGQGARDFPLLGAQMRAAVADATETALSRIAFVRFGSIPRTT
SGKIRRRETGLLLARDALPIVHDDRGGRPAEGEEAGPAPASADPQTPPLERLRLEAARLL
GLEKPPMADTPLVALGIDSLRAAELADWVAETFGTSLPLSTFFTETATLAEIARAIGSSP
QSGGLALFPPPAAVARDVVPLTRGQQTLWVAARRAPESVGNTLSLGVVVGETPPQTLQSA
LDRLSLAHPLLRSVFRLRENDPVRVVHAQPEVTIAPIVWHGEDEGREEALDAFLRQPLVL
EDGPPWRAGLLRNGRSTLLVLALHHILADGRALVLLGKALAAEIDAGTTAAPDDAPAADR
FAEAVGEEEAYLCRPEAWRALTFFRQSLADLPDPLPLAPAGWDGRPAPRPRIVSLPISPS
RLAGLKRSAAVLGSPPARLMFGLFVLALARLTSRDDLVVSVVSTNRPAGQAMTIGYFANP
LPVRLHLGLEATAPLDRVLIQAMAALSTTLDHRLLPFSEIVRAAVRPGEAQRLLQCVFTH
VGVDEGFQGDLASALAVAQDRPVPFLLRPQEGEAALALTFVEGGGGARLDLAIDDGAVAA
AIGQALPTMIGNLATALAEAPHLPLSGVPAMAASVLERMGQWESGPRAALALREEGWSLG
ALFVRAVRDHAARVALEAGRTRWTYDVLGGQVAAIASQLQDLDLRPGDVVALHMAAGPLW
VACLLATLVRGLSFLTLDPSHPAERNHALLEGARAKVVMAAPGLPPLAELPTLVPADPDA
RTPALSTLLVALSEVDATPAYVIFTSGSTGKPKGVVVAQGGLRDRLLWKIEALDLGPGER
VLQSMQTIFDPALWETLAPLLAGSTLVIADPEVRSSPRRLAETLLSAKITVATCISGMVG
PLGQALAGLGGKGDDLALRRIVAGGEALPNAVARAFVEQTGARIEHFYGPTEATIFCTHQ
GVGPADTLPEDGILPIGRPVAGARVAIVDLTGAPCPPGVIGMVDLSGIGLALGYLGADGA
VIGTGGGFRQHGESRVYASGDLGRWRSDGRIEVLGRQDTQVKIRGVRIDLAEVEAVLLAH
SLVGEAAVIAAKRAGVSTLHAFVTGDQDIDSEALRKDLAGRLPPAMRPTTLRAVSGLPRL
ANGKIDRAALDRQIPEATGPALPAATAPLGPQEPLEATLLRCWQQVLAQPDLGVTDDLFE
RGGHSLLALRVCAMVEDISARVIALDPLLRNVSVREQARAILAGNSGRDDKAPTLTRLST
TASGPDFVCIAAGFGDLRRLKALADALGPRANVWGLFPPALLSAGPAGLAELIAAYRQIL
LQRFGARPFALAGFSVGGVIGLELAATLRAEGLAIDHLVLLDSVFPFLMKLNLRLHDLLR
AMVTFRWTNRLMRFAFGRRLRRFFMDEGLSAHLKAAAYCRQKFGGTVTVVRSRAARPFSA
VLFWPWRLRAKRLAWEDASGFHGSMFSADHVGSLAEAVARLNAATSLPPPPPPLPPRALP
V