Protein Info for Rru_A3064 in Rhodospirillum rubrum S1H

Annotation: Isovaleryl-CoA dehydrogenase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 563 PF02771: Acyl-CoA_dh_N" amino acids 180 to 291 (112 residues), 111.2 bits, see alignment E=7.5e-36 PF02770: Acyl-CoA_dh_M" amino acids 297 to 397 (101 residues), 61.8 bits, see alignment E=1.1e-20 PF00441: Acyl-CoA_dh_1" amino acids 412 to 561 (150 residues), 142.3 bits, see alignment E=2.8e-45 PF08028: Acyl-CoA_dh_2" amino acids 429 to 548 (120 residues), 58.3 bits, see alignment E=2e-19

Best Hits

KEGG orthology group: K14448, (2S)-methylsuccinyl-CoA dehydrogenase (inferred from 100% identity to rru:Rru_A3064)

Predicted SEED Role

"Methylsuccinyl-CoA dehydrogenase, predicted by (Erb et al, 2007)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RPT6 at UniProt or InterPro

Protein Sequence (563 amino acids)

>Rru_A3064 Isovaleryl-CoA dehydrogenase (NCBI) (Rhodospirillum rubrum S1H)
MNALPKAAAKAEASQRSLILPDLLYTCDRAYNTAAQALTQIRSNVAALVSVEDKIDGGLL
EIHQHAAHGLAWFATYVEALGALLDWAHRLEAKGGLGELESLILQGAYSEYLHQIFGGLP
MSQGEFARLADFGIEVRERGLLQTPYTTLLREHGFSAPVKARIAALIADGHFGDPGLEDE
TLTLVREQFRRFAEDKVVPHCHEWHLSDTLIPLDVIAQMAEMGVFGLTVAEEYGGLGMGK
TAMCVVTEELSRAYIGVGSLGTRSEIAAELISLGGTEEQKRQWLPRLASGEILPTAVFTE
PNTGSDLASLRSRAERDGDTYRVTGAKTWITHAARSDLMTLLVRTNPQEGGYKGLSMLLA
EKPRGSDEDPFPAKGMAGGEIKVLGYRGMKEYELSFDGFEVPAANLLGSEEGQGFKQLMA
TFESARIQTAARAVGVAQNAMEVGLRYAQDRVQFGKPLYAFPRVHGKLAWMAVETMVARQ
LTYRAGREKDSGRRCDIEAGMAKLLAARVAWSNADNALQVHGGNGYAEEYPISRILCDAR
ILNIFEGAAEIQAHVIARGLLSR