Protein Info for Rru_A3062 in Rhodospirillum rubrum S1H

Annotation: Methylmalonyl-CoA mutase-like (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 671 PF01642: MM_CoA_mutase" amino acids 15 to 499 (485 residues), 433.7 bits, see alignment E=9.3e-134 TIGR00641: methylmalonyl-CoA mutase N-terminal domain" amino acids 16 to 505 (490 residues), 459.9 bits, see alignment E=9e-142 TIGR00640: methylmalonyl-CoA mutase C-terminal domain" amino acids 536 to 657 (122 residues), 116.7 bits, see alignment E=6.9e-38 PF02310: B12-binding" amino acids 539 to 642 (104 residues), 61.6 bits, see alignment E=6.9e-21

Best Hits

Swiss-Prot: 68% identical to MEAA_METEA: Protein MeaA (meaA) from Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)

KEGG orthology group: K14447, ethylmalonyl-CoA mutase (inferred from 100% identity to rru:Rru_A3062)

Predicted SEED Role

"Ethylmalonyl-CoA mutase, methylsuccinyl-CoA-forming"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RPT8 at UniProt or InterPro

Protein Sequence (671 amino acids)

>Rru_A3062 Methylmalonyl-CoA mutase-like (NCBI) (Rhodospirillum rubrum S1H)
MSGDAASTPKPKLQTRDKPWLFRTYSGHSSARASNALYRTNLARGQTGLSVAFDLPTQTG
YDSDHVLARGEVGKVGVPISHLGDMQTLFEGIPLEKMNTSMTINAPAPWLLALYVATAER
QGADRAALQGTVQNDLIKEYLSRGTYIFPPEPSLRLIGDVIAFTYREIPKWNPTNVCSYH
LQEAGATPEQELAFALATAIAVLDTVKAGGQVPEADFPEVVGRISFFVNAGIRFITEMCK
MRAFCDLWDEICLTRYGVTDEKFRRFRYGVQVNSLGLTEQQPENNVYRILLEMLAVVLSK
NARARAVQLPAWNEALGLPRPWDQQWSLRLQQIVAFETDLLDYGDIFDGSREIAAKVEEL
KTAARDELARIAAMGGAEAAVEAGYMKQKLVESNSRRIGGIESGEQIVVGVNKYTEGADS
PLVGGDGAIMTVDPAVEAEQIAALTAWKAARDAKDVGAALDGLRRAAAEGTNIMEPTIAC
AHAGVTTGEWSQTLREVFGEYRAPTGVGRAAAQPEAGGRLAEVRLRVDDLSTRLGRRLKI
LVGKPGLDGHSNGAEQIAVRARDSGMEVVYEGIRLTPAQIVNAALEESVHVVGLSILSGS
HVPLVSDVLDRMRAEGLADIPVIVGGIIPPEDEKILLAAGVARVYTPKDYDITAIMADIV
GIVDLTTRQAA