Protein Info for Rru_A3053 in Rhodospirillum rubrum S1H
Annotation: Homoserine kinase ThrB (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to KHSE_RHORT: Homoserine kinase (thrB) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
KEGG orthology group: K02204, homoserine kinase type II [EC: 2.7.1.39] (inferred from 100% identity to rru:Rru_A3053)Predicted SEED Role
"Homoserine kinase (EC 2.7.1.39)" in subsystem Methionine Biosynthesis or Threonine and Homoserine Biosynthesis (EC 2.7.1.39)
MetaCyc Pathways
- aspartate superpathway (23/25 steps found)
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- superpathway of L-threonine biosynthesis (6/6 steps found)
- L-methionine biosynthesis II (5/6 steps found)
- L-threonine biosynthesis (2/2 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.1.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RPU7 at UniProt or InterPro
Protein Sequence (321 amino acids)
>Rru_A3053 Homoserine kinase ThrB (NCBI) (Rhodospirillum rubrum S1H) MAVYTDVSDDDLTTFLEGYDIGRLRACKGIAEGVENSNFLLVTDRGPHILTLYEKRVNPD DLPFFLGLLRHLAARDIPCPQPVAGRDGAVLHTLCDRPAAIVTFLDGVWPKRPEVRHCAQ LGEALARLHLAGGDYAPTRRNSLSVDGWRPLFDAAAERADSVKPGLRAELETELDALEAL WPHDLPTGIIHADLFPDNVFFVDDTLSGLIDFYFACDDFLAYDLAVCLNAWCFEGEREFN VTKARHMLTRYEKVRPLSDAEFAALPLLARGAAMRFLLTRLYDWLNTPPGAMVRPKDPME YYHKLAFHRAVSGPGAYGLSR