Protein Info for Rru_A2971 in Rhodospirillum rubrum S1H

Annotation: Drug resistance transporter Bcr/CflA subfamily (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 transmembrane" amino acids 20 to 42 (23 residues), see Phobius details amino acids 57 to 74 (18 residues), see Phobius details amino acids 86 to 105 (20 residues), see Phobius details amino acids 111 to 132 (22 residues), see Phobius details amino acids 144 to 166 (23 residues), see Phobius details amino acids 172 to 192 (21 residues), see Phobius details amino acids 225 to 244 (20 residues), see Phobius details amino acids 258 to 280 (23 residues), see Phobius details amino acids 292 to 309 (18 residues), see Phobius details amino acids 315 to 336 (22 residues), see Phobius details amino acids 347 to 369 (23 residues), see Phobius details amino acids 381 to 399 (19 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 19 to 383 (365 residues), 216.1 bits, see alignment E=5.5e-68 PF07690: MFS_1" amino acids 24 to 365 (342 residues), 145.9 bits, see alignment E=3.1e-46 PF06609: TRI12" amino acids 30 to 187 (158 residues), 29.8 bits, see alignment E=4.6e-11 PF00083: Sugar_tr" amino acids 57 to 192 (136 residues), 30.9 bits, see alignment E=2.8e-11

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 100% identity to rru:Rru_A2971)

Predicted SEED Role

"MFS family multidrug efflux protein, similarity to bicyclomycin resistance protein Bcr"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RQ29 at UniProt or InterPro

Protein Sequence (410 amino acids)

>Rru_A2971 Drug resistance transporter Bcr/CflA subfamily (NCBI) (Rhodospirillum rubrum S1H)
MPQLSPPTDRHREIGFPEFVGLMAMLMALTALSIDVMLVALADISSDYFLADANDRQLVI
TAYLLGFAVGQPVWGPLSDRIGRKPVLIAGLVIYGLGCLGAMVSPSFETLLAARLVQGLG
GASPRVMTMAVVRDRYAGSGMARVMSLLMMIFIIVPILAPTMGSAVMAFAPWHWLFGFMM
VFDLIVLVWTLTRLRETHRPQRQLAPSLGGLLETLRVVVSNRQTVGYTVAFGFMMGSLMG
YVGTAQQVFVEVYHEVELFPILFGAIASAIAAASIINARFVTRIGSRRMSHAALLGFVAV
GLVTAAFGFPAKPPLALFMAALGIQFFCFGLIGPNFNAMAMEPMGRVAGAASSFVGFYST
AASAFLGWAVGQQFDDSVRPLMMGFAGFGILALVCVLVTERGRLFRRAAA