Protein Info for Rru_A2947 in Rhodospirillum rubrum S1H

Annotation: Glucose-6-phosphate isomerase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00342: PGI
  • amino acids 49 to 538 (490 residues), 774.3 bits, E=2.4e-237

Best Hits

Swiss-Prot: 100% identical to G6PI_RHORT: Glucose-6-phosphate isomerase (pgi) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K01810, glucose-6-phosphate isomerase [EC: 5.3.1.9] (inferred from 100% identity to rru:Rru_A2947)

MetaCyc: 63% identical to glucose-6-phosphate isomerase (Escherichia coli K-12 substr. MG1655)
Glucose-6-phosphate isomerase. [EC: 5.3.1.9]

Predicted SEED Role

"Glucose-6-phosphate isomerase (EC 5.3.1.9)" in subsystem Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 5.3.1.9)

MetaCyc Pathways

• colanic acid building blocks biosynthesis (11/11 steps found)
• homolactic fermentation (11/12 steps found)
• Bifidobacterium shunt (13/15 steps found)
• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• glycolysis III (from glucose) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• gluconeogenesis III (10/12 steps found)
• superpathway of anaerobic sucrose degradation (15/19 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (20/26 steps found)
• GDP-mannose biosynthesis (4/4 steps found)
• gluconeogenesis I (10/13 steps found)
• glycolysis I (from glucose 6-phosphate) (10/13 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• sucrose biosynthesis II (6/8 steps found)
• sucrose degradation III (sucrose invertase) (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• 1,5-anhydrofructose degradation (3/5 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (4/7 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (9/14 steps found)
• D-sorbitol biosynthesis I (1/3 steps found)
• sucrose biosynthesis III (1/3 steps found)
• glycolysis V (Pyrococcus) (6/10 steps found)
• starch biosynthesis (6/10 steps found)
• 1,3-propanediol biosynthesis (engineered) (5/9 steps found)
• chitin biosynthesis (5/9 steps found)
• heterolactic fermentation (11/18 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (10/17 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• formaldehyde oxidation I (2/6 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (8/18 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (21/56 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Glycolysis / Gluconeogenesis
• Pentose phosphate pathway
• Starch and sucrose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.9

Sequence Analysis Tools

See Q2RQ51 at UniProt or InterPro

Protein Sequence (547 amino acids)

>Rru_A2947 Glucose-6-phosphate isomerase (NCBI) (Rhodospirillum rubrum S1H)
MPDPTTLSAWAALAAHAPTLSDQPLRVLFDADPDRFARFHLRFEDLVLDYSKNRITGETM
ALLADLARQSGVEARRDAMFAGEPINTTEGRAVLHVALRDPTPTPVLVDGADVKPAIAAV
LAHMEAFSEAVRSGAWTGATGKAITDVVNIGIGGSDLGPVMVVEALKAYAKPGLRVHFVS
NVDGTHIAETLKGLSPETTLFLVASKTFTTQETLTNAHTARDWLVGALGEPAVARHFAAL
STNAKAVSAFGIDTANMFEFWDWVGGRYSLWSAIGLPIAISVGFANFRALLDGAHAMDTH
FREAPIERNLPVILGLLGVWYGDFLGARAQAVLPYDQYLHRLAAYLQQADMESNGKRTTL
DGKTVAYATGAVLFGEPGTNGQHSFYQLIHQGTSLIPCDFIAPAISHNPLGRHHAILLSN
FLAQTEALMRGKTEAEARAELAAQGLAGEALEALLPHKVFPGNRPTNAILVKRLDPRTLG
MLIALYEHKIHVQATVWNINAYDQWGVELGKQLAKAILPELEDATISPAHDSSTNGLIAL
YREFSAG