Protein Info for Rru_A2886 in Rhodospirillum rubrum S1H
Annotation: Carbamoyl-phosphate synthase, large subunit, glutamine-dependent (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Predicted SEED Role
"Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)" in subsystem De Novo Pyrimidine Synthesis or Macromolecular synthesis operon (EC 6.3.5.5)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
- L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
- superpathway of arginine and polyamine biosynthesis (14/17 steps found)
- UMP biosynthesis II (6/6 steps found)
- L-arginine biosynthesis I (via L-ornithine) (8/9 steps found)
- superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
- L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
- glutaminyl-tRNAgln biosynthesis via transamidation (4/4 steps found)
- L-citrulline degradation (3/3 steps found)
- ammonia assimilation cycle III (3/3 steps found)
- UMP biosynthesis I (5/6 steps found)
- UMP biosynthesis III (5/6 steps found)
- L-glutamate biosynthesis I (2/2 steps found)
- L-arginine biosynthesis III (via N-acetyl-L-citrulline) (7/9 steps found)
- L-glutamine degradation I (1/1 steps found)
- L-citrulline biosynthesis (6/8 steps found)
- L-arginine degradation V (arginine deiminase pathway) (3/4 steps found)
- superpathway of L-citrulline metabolism (8/12 steps found)
- L-glutamate and L-glutamine biosynthesis (4/7 steps found)
- L-arginine biosynthesis IV (archaea) (4/9 steps found)
- allantoin degradation IV (anaerobic) (2/9 steps found)
- guadinomine B biosynthesis (2/13 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 6.3.5.5
Use Curated BLAST to search for 6.3.5.5
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RQB2 at UniProt or InterPro
Protein Sequence (1082 amino acids)
>Rru_A2886 Carbamoyl-phosphate synthase, large subunit, glutamine-dependent (NCBI) (Rhodospirillum rubrum S1H) MPKRTDIKSILIIGAGPIVIGQACEFDYSGAQACKALRAEGYRVILVNSNPATIMTDPET ADATYIEPITPEIVEAIIERERPDALLPTMGGQTALNTAMALADRGVLTKYGVEMIAANK EVIAKAEDRLLFRDAMRKIGLDCPRSALVHSIEESRQALEEIGLPVIIRPSFTLGGQGGG MAFNREEYDRIVASGLAASPVRQILVEESVLGWKEYEMEVVRDRADNCIIVCSIENIDPM GVHTGDSITVAPALTLTDKEYQVMRNASIACLREIGVETGGSNVQFAVNPKDGRLVVIEM NPRVSRSSALASKATGFPIAKIAAKLAVGYTLDELSNDITGVTPASFEPTIDYVVTKLPR FTFEKFPDTEALLSSSMKSVGEAMAIGRTFKESLQKGLRSLEIGLDGLDEVEIPGSAGQD GKDAIRAALSKARPDRILIIAQALRQGFTVEEVRAICYYDPWFLEQIKEIVDEERRLREN GLPGDAVSLHRVKKMGFSDARLAKLTGKTVTEVSFRRQVLNVHPVYKRIDTCAAEFASRT PYMYSCYEGDGLTPAECEAEVSDRTKIIILGGGPNRIGQGIEFDYCCVHAAYALSDAGFE TIMVNCNPETVSTDYDTSDRLYFEPLTIEDVVELARKEQARGTLLGCIVQYGGQTPLKLA RGLEAAGIPVLGTSPDAIDLAEDRDRFQKLIAKLALRQPRNGTALSVEQARAIATRVGYP VVIRPSYVLGGRAMQIVHDEAQLNDYMVNAVKVSGDDPVLIDNYLSGAIEVDVDAIADGE TTHIAGIMQHIEEAGIHSGDSACSLPPYSLDEATIAELTKQTEALAKGLNVRGLMNIQFA IKDGDIYILEVNPRASRTVPFVAKATGVAVAKIAARVMAGESLASFGLVTKRLAHVAVKE AVFPFARFPGVDIVLGPEMKSTGEVMGIDTTFARAFAKSQLGAGVTLPEGGTAFISVRDG DKAAIMPIARELTELGFRLVATRGTAALLAENGLSVEVINKVLEGRPHCVDAMISGDIHL VFNTTEGIQSQKDSFDIRHTALMRNIPHYTTVAGATAAVKAMTALRQGHLEVAPLQEYFK VS