Protein Info for Rru_A2752 in Rhodospirillum rubrum S1H

Annotation: Signal Transduction Histidine Kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 374 PF00989: PAS" amino acids 39 to 149 (111 residues), 25.4 bits, see alignment E=3.1e-09 PF08448: PAS_4" amino acids 43 to 153 (111 residues), 27.1 bits, see alignment E=1e-09 PF07568: HisKA_2" amino acids 172 to 245 (74 residues), 64.5 bits, see alignment E=1.9e-21 PF13581: HATPase_c_2" amino acids 251 to 362 (112 residues), 34.3 bits, see alignment E=5.5e-12 PF02518: HATPase_c" amino acids 270 to 362 (93 residues), 34.5 bits, see alignment E=6e-12

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A2752)

Predicted SEED Role

"COG3920: Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RQP6 at UniProt or InterPro

Protein Sequence (374 amino acids)

>Rru_A2752 Signal Transduction Histidine Kinase (NCBI) (Rhodospirillum rubrum S1H)
MRLKWPAACPLAAEGPIRKAPMTSAQAFAQIEDGVAFAQAIVDTIREPLLVLDKDLRVVC
ASRAFYQTFKLRPEDVAGCPLYRVGEGQWNIPELRVLLETILPQHAVMDAYEIDHDFGES
GRRTMVLNARTVVEKGKGERLILLAMEDVTVQRAAEAAMRDLLAEKDVLLQEMRHRVGNS
LQLIASILMMKARAVSSEEARHHLQDAHQRILSIAAAQQQLQASRPGEAIALAPYLGRLC
ETLTATLIGDARPIVVKVEAVGSAPSNEAASLGLIVTELVINALKHAFRADATAGEILVA
YESAADGAWRLSVTDNGVGTPTESAAKVTPGLGTSIIRALGHQLDARIESVGGPRGTRVS
LTHGAFAPPTVAAS