Protein Info for Rru_A2721 in Rhodospirillum rubrum S1H
Annotation: 2-oxoglutarate synthase, alpha subunit (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00174, 2-oxoglutarate ferredoxin oxidoreductase subunit alpha [EC: 1.2.7.3] (inferred from 100% identity to rru:Rru_A2721)Predicted SEED Role
"2-oxoglutarate oxidoreductase, alpha subunit (EC 1.2.7.3)" (EC 1.2.7.3)
MetaCyc Pathways
- TCA cycle V (2-oxoglutarate synthase) (9/9 steps found)
- TCA cycle VII (acetate-producers) (8/9 steps found)
- reductive TCA cycle I (9/11 steps found)
- incomplete reductive TCA cycle (6/7 steps found)
- TCA cycle VI (Helicobacter) (7/9 steps found)
- reductive TCA cycle II (8/12 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (21/56 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.2.7.3
Use Curated BLAST to search for 1.2.7.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RQS7 at UniProt or InterPro
Protein Sequence (595 amino acids)
>Rru_A2721 2-oxoglutarate synthase, alpha subunit (NCBI) (Rhodospirillum rubrum S1H) MMTVSRKAVSSVSIALTGSGGAGVMTAGQILLDAAARAGFYGLMAKSLGPQIRGGESAAL LRLSTRPVETPDDVYDILLAVDWGNVERFSAELPLAPTSVILADPAQGVVPPVMRAADPI VVDVALKELAAGVPGGRVNMVALGLLAALIGLPQDSLAQVLAETLEKKGPAALDSSLAAL RAGAAAAEAIPGCVCLPAPPSAPARWLISGNEASAFGALKGGIRFVAAYPITPATEILEW LAPELPKVGGCLVQAEDELASINMILGGSFGGVPALTATSGPGLALMTESLGLGVASETP IVVCNVMRGGPSTGIPTKSEQVDLNIALYGLHGDAPHVVTAPNGIGDCAATTQWSVHLAE AMQVPVIVLSDQAMGQSRAIIDKPATRASVAQRLTAPPRAKSDETPYARYGVTASGISPM AVPGTPGCAYTADGLEHSPRGMPSTQASHHGEQLDKRLRKLTGFAYGDAWADIEGDGPTA LITWGSVTAAAREAAARLAEDGIAVRLISLRLIAPALPEAFAQALAGVSRALIVEQNHGR QFYRYLRSVYDLPADTITYNRPGPVVLRPHEIVSAVKSWGARVHPPASEQTGQGE