Protein Info for Rru_A2604 in Rhodospirillum rubrum S1H

Annotation: Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 678 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details transmembrane" amino acids 166 to 188 (23 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 246 to 405 (160 residues), 128.5 bits, see alignment E=1e-41 PF00990: GGDEF" amino acids 248 to 402 (155 residues), 137.6 bits, see alignment E=3.5e-44 PF00563: EAL" amino acids 425 to 655 (231 residues), 242 bits, see alignment E=5.7e-76

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A2604)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RR44 at UniProt or InterPro

Protein Sequence (678 amino acids)

>Rru_A2604 Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) (NCBI) (Rhodospirillum rubrum S1H)
MLGKFLAVQQALRVSLLSLAVSLGFLGMQTVWLASAADRDYLILRDRTASSLQSGLSNAL
WNFDAETAKAIISDALRANPIRSIHVIDSNGRVFADGQSAQPVVAPSLWESYLGWLVDLK
SEMTLDLRFSSPTDDHYQGMVVGFVFITFDKDHFIRGIADRLADQVLGILVIVLVVALTT
SIVFHLFISRPIIRVARGVADVDPEDPAATVLTVPRAHQRNEIGRMTNRLNHLLGRLAEV
QGELRLLATRDPLTDLPNRSLILEMMDATINRVALDGGRCAVMFLDLDMFKHVNDSLGHE
AGDLILKDIGRRFDAVVAGLGAVGRLGGDEFVVLIDRYEREDDLARIARRLITTVKRPIE
VDGTLVHSSTSVGIACYPVDGATPQGLLRNADTAMYAVKASGPGQWAFFDRSMTENALVR
LRTEASLRSAIEKGQFVLHYQPKLDLRSNRISGCEALIRWDLNGDLVPPGRFISIAEETG
MIYDIGLWVLREACQAQRRWRRHAGAVPIAINVSVRQLKDERFIDDFLDIIQASGADPEL
LEVEVTESALMSSIEVSAHLLREMRSHGVRLSIDDFGTGYSSLAYLKNLPIDILKIDRSF
VSDLPEESSIPRMIIGLAGQMGLRTVAEGIETEGQLAWLRDNGCDMIQGFLIEKPLPEAD
FLRFVDAYRTARAFPSAS