Protein Info for Rru_A2520 in Rhodospirillum rubrum S1H

Annotation: Penicillin-binding protein 1A (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 transmembrane" amino acids 38 to 60 (23 residues), see Phobius details PF00912: Transgly" amino acids 90 to 256 (167 residues), 212.3 bits, see alignment E=3.7e-67 TIGR02074: penicillin-binding protein, 1A family" amino acids 95 to 608 (514 residues), 529 bits, see alignment E=7.5e-163 PF00905: Transpeptidase" amino acids 345 to 571 (227 residues), 77.3 bits, see alignment E=1.3e-25

Best Hits

KEGG orthology group: K05364, peptidoglycan glycosyltransferase [EC: 2.4.1.129] (inferred from 100% identity to rru:Rru_A2520)

Predicted SEED Role

"Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)" in subsystem Peptidoglycan Biosynthesis or Type IV pilus (EC 2.4.1.129, EC 3.4.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129, 3.4.-.-

Use Curated BLAST to search for 2.4.1.129 or 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RRC5 at UniProt or InterPro

Protein Sequence (750 amino acids)

>Rru_A2520 Penicillin-binding protein 1A (NCBI) (Rhodospirillum rubrum S1H)
MIPSPSDRLSGNRRPEDIDPPEAPRPPRRPALRHPGRIALAIAGVVLALGVLVLAINLYT
MPLSPSFQEPERSGFLIADAEGTVVATRGVTAGRPVALAEMPASLVNAVIAFEDRRFRDH
WGVDPRGIARAIWVNLRSGGRTQGASTLTQQLVKNTLLTPEKTFTRKIQEAMLALWIERK
LTKDEILERYLNSLYLGAGSYGVDAAARRYFNKPVTDLSLAESAMIAGLIQAPARTGPTT
ALDVARQRAELVLDVMRDQGLIGADEATWAKAHPASLAVPPVELPAYGAVSDWIADEARK
ALGPLSGDFLVVSTLDRRLQVLAQQTIQEGMAAEGAGLRATQAALVAMAPDGRVLAMVGG
RDYQESQFNRAVQARRQPGSIFKLFVYLTALSNNWRPDDPIDDTPLTIDGWSPENYGGGA
GHGSVPLRVAFAHSYNLAAVRLQEAVGREAVIATARSMGLKDDLQPLPSLALGTFPATLL
DLTSAFAAVAADRATVQPRVIEVLRTPGSGEIRPPVRQSGRAPWPRASALDLLNAVVTQG
TGRAAALGVPTYGKTGTTQDNRDAWFIGFAGNLVIGVWVGNDDETPMTGISGGGLPAKLW
QSFAARALAGGVAGSAPAAPIAAATTATLPAAAPPAPTPAPAVPSRQPFSAVPEAVVDTG
TLRLGGRVVRLEGVKGLTGRPARDMAGYIGDRSVTCRPAGRERWRCDVEGWDLSEVALFN
GGARATADAPADLVAAERKARQAGRGVWGR