Protein Info for Rru_A2511 in Rhodospirillum rubrum S1H

Annotation: Putative diguanylate cyclase (GGDEF domain) (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 686 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details transmembrane" amino acids 345 to 365 (21 residues), see Phobius details PF09084: NMT1" amino acids 56 to 262 (207 residues), 185.8 bits, see alignment E=1.1e-58 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 511 to 674 (164 residues), 140.6 bits, see alignment E=3.9e-45 PF00990: GGDEF" amino acids 515 to 670 (156 residues), 130.9 bits, see alignment E=3.8e-42

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A2511)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RRD4 at UniProt or InterPro

Protein Sequence (686 amino acids)

>Rru_A2511 Putative diguanylate cyclase (GGDEF domain) (NCBI) (Rhodospirillum rubrum S1H)
MQAFPAYPSRRKWRRRLFLLGVIGLLACVNGALALAQGAPPPQDEPLHLRLKWKHQFQFA
GYYAALEKGFYAGEGLSVVLEEASDSEDAVTAVLAGKAQYGIDSTELLVAYGRGEPVVAL
AALFQHSPEVLLARTDSGITLLHDLIGRRISLPPASLSLLAYLAAEGIGANQMTIVRNPF
SPDPLLQGEVDAIGAYSSDEPYSLRRQGIDFLMFSPRSAGIDLYGDILFTTAAELRSHPD
RVRAFRRASLRGWEYALAHPQEIARLIADRYPGQRTIDHLLFEAAAMRQLIAADLIEPGY
MTRGRWQAIADLYAGFGMIGRDLDLGPFLYGLAETDRTPRIPPGLLPASGLIGAFGLVAV
FGLLRYRKIKRALTREIGERRIVESHLRQSETRYRMMIEAAPFGVLISSLSTDHIVQINA
RAEDQLQAMRHWVIDKPFADLFVDPADHRRLLDTLNKTGSIANFVALLRTATDNDFWAEL
SAAVIDLDRSPAVFASFNDISQTKALERELRALAERDSLTGLANRLRVMDALRSEFDRVT
RYGGALSVMMLDLDRFKVLNDRHGHVCGDEALRHFAASALATLRTNDLLGRSGGEEFIVL
LPGAALGAAKLIGERLRAAVQDKPLSWQGRSVALSVSIGLASRQIGDTPDSLLGRADQAL
HLAKANGRNRLETADGPPTTATVIPL