Protein Info for Rru_A2480 in Rhodospirillum rubrum S1H
Annotation: Methylmalonyl-CoA mutase (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01847, methylmalonyl-CoA mutase [EC: 5.4.99.2] (inferred from 100% identity to rru:Rru_A2480)Predicted SEED Role
No annotation
MetaCyc Pathways
- superpathway of anaerobic energy metabolism (invertebrates) (14/17 steps found)
- methylaspartate cycle (15/19 steps found)
- propanoyl CoA degradation I (3/3 steps found)
- (S)-lactate fermentation to propanoate, acetate and hydrogen (10/13 steps found)
- 3-hydroxypropanoate cycle (10/13 steps found)
- 2-oxobutanoate degradation I (3/4 steps found)
- pyruvate fermentation to propanoate I (5/7 steps found)
- anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
- superpathway of the 3-hydroxypropanoate cycle (12/18 steps found)
- conversion of succinate to propanoate (1/3 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
- superpathway of L-methionine salvage and degradation (9/16 steps found)
- L-glutamate degradation VIII (to propanoate) (5/11 steps found)
- crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (6/14 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 5.4.99.2
Use Curated BLAST to search for 5.4.99.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RRG5 at UniProt or InterPro
Protein Sequence (698 amino acids)
>Rru_A2480 Methylmalonyl-CoA mutase (NCBI) (Rhodospirillum rubrum S1H) MTQDILALAGDFPTLSREAWLALVDKALKGAPFEKKMVTKTHEGFSIQPLYTRADWPSTG DPSGFPGVMPFTRGGTAAGAVLHGWDVRQEHAHPDPAAANAQILTDLERGASSVTLRFDA AGRAGFDSDDAEAADLAGVEGMMIASLDDLDTALAGVFLDGAVVGLQAGAAFEPAAALLA ALWARRQIAPAAALGAFNADPLGTLAATGSLPMSATRALSRLGALAAHTARSYPQATAVM VDGAPYHDGGANEVQTLAAVLSTGVAYLRAMEAAGLGIDEAAAQMVFSLPLDADIFLGVA KLRAARRLWARVLEASGASEPSRAMRLHATTARRVLTRRDPWVNMLRGTVSCFAGAVGGA DSIAVAPFDAALGVATDFSRRIARNVQVILLEECNLGRVNDPAGGSWYVETLTDRLAREA WSAFQGLEAEGGMVAALESGALAGRIAATWDDRRKAIAKRKDPLTGVSEFPNLAEAPVAT APVDLAALRQAATTRLSAARWDGVAPGDFAAAIEAVGTGATLGALARALGDGAALRVPAV VPHVLAEDFEALRDASDDWLAAHGQRPKIFLANLGPVAQHTARATFAKNFFEAGGIEAVA GAGFDEAADCVAAWRDSGAKVAILCSSDGLYETKAEDMARALKAAGVSRLYLAGAPGERR ALYDAAGVDAYIQAGSDVLGVLGDLHAHLGLAVEGSAR