Protein Info for Rru_A2432 in Rhodospirillum rubrum S1H

Annotation: bifunctional sulfur carrier protein/thiazole synthase protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 329 PF02597: ThiS" amino acids 3 to 66 (64 residues), 45.3 bits, see alignment E=1.1e-15 TIGR01683: thiamine biosynthesis protein ThiS" amino acids 3 to 66 (64 residues), 71.1 bits, see alignment E=3.8e-24 PF05690: ThiG" amino acids 80 to 324 (245 residues), 366 bits, see alignment E=9e-114

Best Hits

Swiss-Prot: 100% identical to THIG_RHORT: Thiazole synthase (thiG) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K03149, thiamine biosynthesis ThiG (inferred from 100% identity to rru:Rru_A2432)

Predicted SEED Role

"Thiazole biosynthesis protein ThiG" in subsystem Thiamin biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RRL3 at UniProt or InterPro

Protein Sequence (329 amino acids)

>Rru_A2432 bifunctional sulfur carrier protein/thiazole synthase protein (RefSeq) (Rhodospirillum rubrum S1H)
MRVIINGEPRELAPSVSIEALLVGMGVDPRKVAVERNREIVARTTYKETALDEGDQLEIV
HFIGGGDRSDPQPADDPFTVAGRVFSSRLLVGTGKYRDFEETARAIEASGAEIVTVAVRR
VNVSDPSQPMLVDYVDPAKYTYLPNTAGCFTADEAVRTLRLAREAGGWSLVKLEVLGDQR
TLYPNMAETFLAAEALIRDGFEVMVYCADDPIAAKRLEDMGCVAIMPLGSLIGSGLGIIN
PYTIRLIKESVSVPVLVDAGVGTASDAAVAMELGCDGVLMNTAIAQAKDPVRMARAMRLA
IEAGRLSYQAGRMPRKLYADPSSPLAGLI