Protein Info for Rru_A2410 in Rhodospirillum rubrum S1H

Annotation: Homoserine dehydrogenase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03447: NAD_binding_3
  • amino acids 11 to 130 (120 residues), 50.6 bits, E=4.4e-17
• PF00742: Homoserine_dh
  • amino acids 139 to 317 (179 residues), 218.5 bits, E=8.5e-69
• PF01842: ACT
  • amino acids 350 to 412 (63 residues), 31.8 bits, E=1.4e-11

Best Hits

Swiss-Prot: 49% identical to DHOM_PSEAE: Homoserine dehydrogenase (hom) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00003, homoserine dehydrogenase [EC: 1.1.1.3] (inferred from 100% identity to rru:Rru_A2410)

Predicted SEED Role

"Homoserine dehydrogenase (EC 1.1.1.3)" in subsystem Methionine Biosynthesis or Threonine and Homoserine Biosynthesis (EC 1.1.1.3)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• L-homoserine biosynthesis (3/3 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (7/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (7/9 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (6/8 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Glycine, serine and threonine metabolism
• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.3

Sequence Analysis Tools

See Q2RRN5 at UniProt or InterPro

Protein Sequence (430 amino acids)

>Rru_A2410 Homoserine dehydrogenase (NCBI) (Rhodospirillum rubrum S1H)
MNDPLKVAVAGLGTVGAGVVKLLADHKDLLAARAGRPVVVSAVSARSRTRDRGVDLSSYA
WFDDPVALVREAKADVVVELIGGSDGPAKAVCETALDLGRPVVTANKALLAHHGLALAAR
AEATGAGLWFEAAVAGGIPIIKALREGLAANRIDALHGILNGTCNYILTTMRESGRDFAD
VLAEAQALGYAEADPGFDIDGIDAAHKLALLASLAFHVPVDLGGVSIQGIRHISSLDIRF
ADELGYRIKLLAMARRTAEGVEQRVAPVMVPLDAPLAHVEGVNNAVVTEGDFVGRSVFQG
RGAGAGPTASAVVADLIDLARGHKVPVFGVPSSALSVLPRAEPEDHVGRYYVRLMVVDRP
GVFAEVAAALRDEQVSMESVLQRARDPGETVPVVMTLHDTGEAAMTRALARIGAIDAMVE
PPRVIRIEQF