Protein Info for Rru_A2361 in Rhodospirillum rubrum S1H

Annotation: Multi-sensor Hybrid Histidine Kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1560 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 309 to 334 (26 residues), see Phobius details PF03924: CHASE" amino acids 83 to 267 (185 residues), 185.5 bits, see alignment E=4.6e-58 TIGR00229: PAS domain S-box protein" amino acids 345 to 469 (125 residues), 76.3 bits, see alignment E=1.2e-25 amino acids 492 to 612 (121 residues), 24.4 bits, see alignment 1.3e-09 amino acids 617 to 739 (123 residues), 59.4 bits, see alignment E=1.9e-20 amino acids 743 to 882 (140 residues), 54.9 bits, see alignment E=4.8e-19 PF00989: PAS" amino acids 348 to 459 (112 residues), 60 bits, see alignment 1.1e-19 amino acids 632 to 724 (93 residues), 24.2 bits, see alignment 1.4e-08 amino acids 758 to 872 (115 residues), 45.5 bits, see alignment 3.5e-15 PF08448: PAS_4" amino acids 354 to 463 (110 residues), 36.6 bits, see alignment 2.4e-12 amino acids 498 to 606 (109 residues), 54.3 bits, see alignment 7.7e-18 amino acids 634 to 734 (101 residues), 26.1 bits, see alignment 4.2e-09 amino acids 758 to 877 (120 residues), 26.2 bits, see alignment 3.9e-09 PF13426: PAS_9" amino acids 358 to 460 (103 residues), 38.7 bits, see alignment 5.3e-13 amino acids 634 to 732 (99 residues), 49.4 bits, see alignment 2.3e-16 amino acids 759 to 873 (115 residues), 48 bits, see alignment 6.5e-16 PF08447: PAS_3" amino acids 370 to 452 (83 residues), 27.7 bits, see alignment 1.3e-09 amino acids 641 to 725 (85 residues), 43.6 bits, see alignment 1.5e-14 PF00512: HisKA" amino acids 896 to 960 (65 residues), 67.4 bits, see alignment (E = 4.5e-22) PF02518: HATPase_c" amino acids 1007 to 1121 (115 residues), 93.9 bits, see alignment 4.5e-30 PF00072: Response_reg" amino acids 1139 to 1258 (120 residues), 48.7 bits, see alignment 4e-16 amino acids 1288 to 1395 (108 residues), 73.4 bits, see alignment 8.3e-24 PF01627: Hpt" amino acids 1454 to 1537 (84 residues), 43.8 bits, see alignment 1.3e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A2361)

Predicted SEED Role

"COG2202: FOG: PAS/PAC domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RRT4 at UniProt or InterPro

Protein Sequence (1560 amino acids)

>Rru_A2361 Multi-sensor Hybrid Histidine Kinase (NCBI) (Rhodospirillum rubrum S1H)
MTGTTGLGRRIVWWWIVGAVLAGIGLSGFAVWWVTQRNAELAETAASLELTRLSDAIAER
ITLYQYGLRGARGVIVTFGERGITREVFRGYSKTRDIGAEFPGARGFGFIRRVPADREER
FLAEARADGWPDFAIAQFTPHEGERFVIQYIEPAQRNLKAVGLDIASEKNRREAALAAID
TGQVRLTGPITLVQASGDKSQSFLILLPIYRTLSTPETLAERRAQAFGWSYAPLNMPEVL
SGLVPNQDRLALTLRDVTNPAEAETVFTSNTDCAAAECVTKTLTRSIFGRVWEISVTVSP
AYGHAVQRIAPWVVVSLGIGASILAAGFAAVIGLNQARRREIAQAQARLSTIVENSGDAI
IGEALDGTIVGWNRAAEALFGYKAPEVIGKALAPLLIPADRMAENQSIVLSALSGEAVMA
FDTQRIHADGHLFDVSMTACPVHDRLGHVVGVANLIRDIRKRKAAEQSLLEFNAQLEKQV
ASRTAELEKARRALQTVLDSVPSMIGYWDRDLHCHIANRAYCSWFNVDPSGLIGKSMRSL
LGEALFTANRPFIEAVLRGQPQTFERMIPRPNGQGVRHSLAHYIPDVVDGEVLGFYALVH
DVSELVEGRQKLDAALRENEALLRTIDEQLLCSITDRNGNIISINDNFCKLMGYTKDELL
GLDHRIMNSGLHDKTFWADVWATISAGGSWRGEVCNKAKDGALYWLDSVLTPFFGEDGSI
DRYVALRIDITDRKKAEAERNRSNTLLRSVLASAREFSIIATDPDGVITIFNSGAEKLLG
YSAEEMVGKQTPALIHLADQVAERGRSLSDEFGVPIEGFRVFVHRSERDGVEAQEWTYVR
KDGGHLEVLLVVTAIREDDGRIAGYLGVAQDVSRRKEFERALVLAKQAAEEASVVKGQFL
ANMSHEIRTPMNAILGMLTLVQRTALTPHQADYVCKAHSAAGSLLGLLNDILDFSKIEAG
KLHLEPHPFRLETVLRDLAVVLSGSYGDKGVEVLFDIAPHLPDSFIGDDLRLRQVLLNLA
GNALKFTDQGQVIVSVGVLAREDDRLTMRMAVSDTGIGIAADQLASIFGAFEQAETSTTR
RFGGSGLGLTITRHLVERMGGVLRVESQPGRGSRFWFDITLPVSGEGSESAESGRPLRVL
VVEDNPVAGGILAQTVQGLGYDCDLVQESAETKARIVAADAAGRPYDAVLLDWRMPEVDG
LTTARILREMGVTLCPQSIIMVTAYGRDVLSLAEQTGDAPFDAVLTKPVTPGQLRDALLR
RDRATSEGEATALAPRGLPTPLAGRRLLVVEDNAINRQVAAELLAGAGAEIDLAEGGERG
VMMVLRGEIAYDAVLMDIQMPDIDGFEATRRIRADARFKALPIVAMTANASRADREACLA
AGMTEHVGKPIDITATIDVLVSLMTEGMTEGEPIAPPSPMGGTGREVPSDEPLLEDLDSI
AERLGGQVDLLRRLLPTFAERTGELLDEIEDLIGRGDWSALSMAFHTIKGSAASMGAVAL
ASHAALWEERLREDGPGTLDALRRDQALCDQMRALLAASLEALSSHLDAMAGPYAKEPAG