Protein Info for Rru_A2255 in Rhodospirillum rubrum S1H

Annotation: Uracil phosphoribosyl transferase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 75% identical to UPP_RHOCS: Uracil phosphoribosyltransferase (upp) from Rhodospirillum centenum (strain ATCC 51521 / SW)

KEGG orthology group: K00761, uracil phosphoribosyltransferase [EC: 2.4.2.9] (inferred from 100% identity to rru:Rru_A2255)

MetaCyc: 49% identical to uracil phosphoribosyltransferase (Escherichia coli K-12 substr. MG1655)
Uracil phosphoribosyltransferase. [EC: 2.4.2.9]

Predicted SEED Role

"Uracil phosphoribosyltransferase (EC 2.4.2.9)" in subsystem De Novo Pyrimidine Synthesis or LMPTP YwlE cluster (EC 2.4.2.9)

MetaCyc Pathways

superpathway of pyrimidine nucleobases salvage (4/4 steps found)
pyrimidine nucleobases salvage II (2/2 steps found)
pyrimidine nucleobases salvage I (1/1 steps found)
superpathway of pyrimidine ribonucleosides salvage (6/10 steps found)

KEGG Metabolic Maps

Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RS40 at UniProt or InterPro

Protein Sequence (218 amino acids)

>Rru_A2255 Uracil phosphoribosyl transferase (NCBI) (Rhodospirillum rubrum S1H)
MSATAHPDFPNLFVLDHPLIQHKLTHMRRRETSTRTFRMLLREIALLMGYEVTRSLPLTT
ESIETPLEAMEAPVIGGKKLVVVPILRAGQGMADGLLELVPSARVGHIGLYRDEVTRQPV
EYLVKLPETTERTFILVDPMLATGHSGAHAATVLLRHGVPAERIRFMALVAAPEGVRTFH
AAHPDVPVYVAALDRQLNDQAFICPGLGDAGDRLFGTK