Protein Info for Rru_A2127 in Rhodospirillum rubrum S1H

Annotation: Serine 3-dehydrogenase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 255 PF08659: KR" amino acids 4 to 164 (161 residues), 50.7 bits, see alignment E=3.3e-17 PF00106: adh_short" amino acids 4 to 188 (185 residues), 176.7 bits, see alignment E=6.1e-56 PF13561: adh_short_C2" amino acids 9 to 223 (215 residues), 124.8 bits, see alignment E=6.6e-40

Best Hits

Swiss-Prot: 62% identical to ISFD_CHRSD: Sulfoacetaldehyde reductase (isfD) from Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)

KEGG orthology group: K05886, serine 3-dehydrogenase [EC: 1.1.1.276] (inferred from 100% identity to rru:Rru_A2127)

MetaCyc: 62% identical to sulfoacetaldehyde reductase monomer (Chromohalobacter salexigens DSM 3043)
RXN-12148 [EC: 1.1.1.313]

Predicted SEED Role

"Oxidoreductase, short chain dehydrogenase/reductase family" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.276 or 1.1.1.313

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RSG8 at UniProt or InterPro

Protein Sequence (255 amino acids)

>Rru_A2127 Serine 3-dehydrogenase (NCBI) (Rhodospirillum rubrum S1H)
MTNTVFITGATAGFGEACARRFAEAGWALVLTGRRAERLEALKAELGASVPVHAAVMDVR
DRASVQAVIAALPAPFDKVHTLINNAGLAAGLEKAAEASLDDWQTMIDTNVTGLVTCTHA
LLPRLIAAGNGSIINLGSVAGRWPYPGGSVYGGTKAFVRQFSLNLRNDLLGTGVRVTDIE
PGMAESEFSIVRFKGDREAASKVYAGVDPLTPKDIAETIFWVATQPPHININTLEIMPVA
QAWAGFAVHRRPAAE