Protein Info for Rru_A2005 in Rhodospirillum rubrum S1H

Annotation: Glutaryl-CoA dehydrogenase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 69% identical to GCDH_BOVIN: Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) from Bos taurus

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 100% identity to rru:Rru_A2005)

MetaCyc: 72% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

glutaryl-CoA degradation (3/5 steps found)
L-tryptophan degradation III (eukaryotic) (3/15 steps found)
crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
toluene degradation VI (anaerobic) (3/18 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RSU0 at UniProt or InterPro

Protein Sequence (395 amino acids)

>Rru_A2005 Glutaryl-CoA dehydrogenase (NCBI) (Rhodospirillum rubrum S1H)
MTRSPLANWDDLLDLDGALAEDERMIRDSARAYCQDKLMPRVVEANRHEHFDRAIMTEMG
ALGLLGPTIPEEYGGPGVNHVAYGLIAREVERVDSGYRSAMSVQSSLVMHPIYAYGSDAQ
KATWLPALASGEKIGCFGLTEPDHGSDPGSMKTRATKTAGGYRLNGAKMWITNSPIADLA
VVWAKSEAHDDKIRGFLVERGMKGFSTPKIEGKFSLRASLTGEIVLDDCVVPEANLLPLA
EGLAGPFGCLNKARYGISWGAMGAAEFCWHAARQYTLDRLQFGRPLAATQLIQKKLADMQ
TEITLGLLGSLRVGRLLDEGKARPEAISLVKRNNAGKALDIARVARDMHGGNGIADEFHV
IRHVMNLESVNTYEGTHDVHALILGRAQTGLQAFF