Protein Info for Rru_A1958 in Rhodospirillum rubrum S1H
Annotation: GMP reductase (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00364, GMP reductase [EC: 1.7.1.7] (inferred from 100% identity to rru:Rru_A1958)MetaCyc: 55% identical to ToyE (Streptomyces rimosus)
1.7.1.-
Predicted SEED Role
"Inosine-5'-monophosphate dehydrogenase, catalytic domain (EC 1.1.1.205)" (EC 1.1.1.205)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
- superpathway of purine nucleotide salvage (13/14 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
- guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
- purine nucleotides degradation II (aerobic) (9/11 steps found)
- inosine 5'-phosphate degradation (3/4 steps found)
- toyocamycin biosynthesis (3/5 steps found)
- ureide biosynthesis (3/7 steps found)
- adenosine nucleotides degradation I (3/8 steps found)
- purine nucleotides degradation I (plants) (5/12 steps found)
- superpathway of purines degradation in plants (5/18 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Drug metabolism - other enzymes
- Purine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.205
Use Curated BLAST to search for 1.1.1.205 or 1.7.1.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RSY7 at UniProt or InterPro
Protein Sequence (385 amino acids)
>Rru_A1958 GMP reductase (NCBI) (Rhodospirillum rubrum S1H) MIEGLRSGLSFDDVLLVPGRTRARSRADITLASRFSRRIALALPLVSANVPWCTQAPMAI ALGRLGGLGVLHRMCAIEDQERQVALVKAAPVDGEDAARATVDDGGALIAAAAVGAKPED LERADRLVAAGCDALVVDIAHGHADYALDTIAALKSRHPQIDVIGGNVATAEGTADLIAA GADAIKVGIGPGGICTTRRVAGAGVPQMTAIADCVGVARARNVPVIADGGIRFSGDIVKA LAVGAASVMLGSLLAGTDESAAVFIDHQGRRCKATTGFVTLGVGLTRKRLRGEKINAEDL DAYVAEGVESTFEASGPLARLIGQLAGGIRSGVSYGGALSIAELQDKARFIRVSEAGRAE SRPHALDRAPAPPPDYARLFVEEEA