Protein Info for Rru_A1887 in Rhodospirillum rubrum S1H

Annotation: CTP synthase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00337: CTP synthase
  • amino acids 2 to 534 (533 residues), 757.6 bits, E=3.4e-232
• PF06418: CTP_synth_N
  • amino acids 3 to 265 (263 residues), 401.5 bits, E=2.5e-124
• PF00117: GATase
  • amino acids 301 to 533 (233 residues), 143.8 bits, E=7.7e-46

Best Hits

Swiss-Prot: 100% identical to PYRG_RHORT: CTP synthase (pyrG) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K01937, CTP synthase [EC: 6.3.4.2] (inferred from 100% identity to rru:Rru_A1887)

MetaCyc: 59% identical to CTP synthetase (Escherichia coli K-12 substr. MG1655)
CTP synthase. [EC: 6.3.4.2]

Predicted SEED Role

"CTP synthase (EC 6.3.4.2)" (EC 6.3.4.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (4/4 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• L-glutamate and L-glutamine biosynthesis (4/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)
• superpathway of pyrimidine ribonucleosides salvage (6/10 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.2

Sequence Analysis Tools

See Q2RT58 at UniProt or InterPro

Protein Sequence (542 amino acids)

>Rru_A1887 CTP synthase (NCBI) (Rhodospirillum rubrum S1H)
MTRFIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNVDPGTMSPTQHGEVF
VTDDGAETDLDLGHYERFTGVSARRSDNVTTGRIYSDVIARERRGDYLGKTVQVIPHVTD
AIKEFATADLTDEDFVLCEIGGTVGDIESLPFLEAIRQLRNEMGAERSLIIHLTLLPYIP
SAGELKTKPTQHSVKELLGLGIQPDLLMCRSDRPIPEAERNKISLFCNVRREAVIPALDV
DTIYQVPVSYHAQGLDVQVCRHFHLPMNEDLDLTRWQTIVDRVRHPEGEVTIAVVGKYTS
LIDSYKSLAEALVHGGIANAVKVKLVWLDSEIFEREDAVHYLEGVNGILVPGGFGERGSE
GKIEAARFARERSVPYFGICFGMQMAVIEFARHVAGLPGASSSEFGVPEVPLVGLMTEWV
RGNERVARGSGDDLGGTMRLGAYECHLRALSKVREIYGAEVIHERHRHRYEVNVTFKDQL
EEKGLAFSGMSPDGVLPEIVELPDHPWFIGVQFHPELKSKPFDPHPLFTSFVQAAITQSR
LV