Protein Info for Rru_A1798 in Rhodospirillum rubrum S1H

Annotation: Type I secretion outer membrane protein, TolC (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 538 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details TIGR01844: type I secretion outer membrane protein, TolC family" amino acids 77 to 486 (410 residues), 332.2 bits, see alignment E=2.5e-103 PF02321: OEP" amino acids 80 to 267 (188 residues), 99.6 bits, see alignment E=9.8e-33 amino acids 286 to 471 (186 residues), 114.4 bits, see alignment E=3e-37

Best Hits

KEGG orthology group: K12340, outer membrane channel protein TolC (inferred from 100% identity to rru:Rru_A1798)

Predicted SEED Role

"Type I secretion outer membrane protein, TolC precursor" in subsystem Multidrug Resistance Efflux Pumps or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RTE7 at UniProt or InterPro

Protein Sequence (538 amino acids)

>Rru_A1798 Type I secretion outer membrane protein, TolC (NCBI) (Rhodospirillum rubrum S1H)
MFCVAPLWWSCILTKGEATPFLCDDLRLAVPFGARAERAPERTVFEAFREKLMIKPVSIA
VASLLVAGLGLSSPVMAETFDEALVSAYQANPTLQARRALLRAVDEQVPQALSDWRPQVS
VQGSTFYQQMDYEPGRKNLDNRPATLGVVLQQNIFRGLRTVAQTDQAKAQVQSERALLRS
VEQTVLLNAAQAYFNVIRDQAVLELNINNEQVLRRQLDAANDRFRVGEITRTDVAQADSR
LAGAIADRIQAEGTLESSRANYTQVVGHPPENIQPPPPYARLPQTLEDGLNTALSANPDV
IAALYVWRQAQAAIRDQRGKLLPTLNAEVSYSFSHNPSATTEYDTKTFQAGLNLTVPLYQ
GGAVYSQIRDAKHRAGQRRLQVDEQREAVIESLTSAWETLTSARARVSSYKSQIEAAGIA
LDGVQREAQVGSRTVLDVLDAEQELLTSRVNLVRAERDSAISTYEVLAALGAMTAEDLGL
NTPLYDATAHYNDVKGQWIGGNDLANQDEDLIVKTAPPIDGDSMTRPVRALDSATGTR