Protein Info for Rru_A1593 in Rhodospirillum rubrum S1H

Annotation: Peptidase M50, putative membrane-associated zinc metallopeptidase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 367 transmembrane" amino acids 6 to 29 (24 residues), see Phobius details amino acids 107 to 131 (25 residues), see Phobius details amino acids 291 to 314 (24 residues), see Phobius details amino acids 341 to 361 (21 residues), see Phobius details PF02163: Peptidase_M50" amino acids 11 to 352 (342 residues), 239.2 bits, see alignment E=6.7e-75 TIGR00054: RIP metalloprotease RseP" amino acids 134 to 363 (230 residues), 179.1 bits, see alignment E=7e-57 PF00595: PDZ" amino acids 134 to 176 (43 residues), 28 bits, see alignment 4.7e-10 PF13180: PDZ_2" amino acids 138 to 198 (61 residues), 31.4 bits, see alignment E=4e-11 PF17820: PDZ_6" amino acids 140 to 193 (54 residues), 46.8 bits, see alignment 4.1e-16

Best Hits

Swiss-Prot: 46% identical to Y1501_RHIME: Putative zinc metalloprotease R01501 (R01501) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 100% identity to rru:Rru_A1593)

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RU02 at UniProt or InterPro

Protein Sequence (367 amino acids)

>Rru_A1593 Peptidase M50, putative membrane-associated zinc metallopeptidase (NCBI) (Rhodospirillum rubrum S1H)
MLDLLHTVLSFLVVLTAVVFVHEFGHFLVARLNGVRVEVFSIGFGRELFGFNDRYGTRWR
LSLLPLGGYVRFFGDADETSGTAETTRPLSKAEEAVSFHHKRVGQRFAIVLAGPMANFLF
SIVVFAGLYMTIGQPHSAPVVGEVIAGSAAAEAGLLAGDRIVAIDGTPIDRFQDVRRVVP
LSNGAPLHIDILRDNAPLAVIALPRMVETDDGLGNKVQVAQLGVKVSLSQADVQRLGPLD
ALGQAVGQTWQLSADTLTYLGQVVRGNRSAEELGGPVRIAQFSGKAAERGVLDLVTFIAL
LSVNLGLINLFPIPMLDGGHLMFYTIEALRGRPLGARAQEYGLRFGLALVLAMMVFATWN
DLSLINW