Protein Info for Rru_A1493 in Rhodospirillum rubrum S1H

Annotation: UDP-N-acetylglucosamine 2-epimerase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00236: UDP-N-acetylglucosamine 2-epimerase
  • amino acids 15 to 380 (366 residues), 382.3 bits, E=1.3e-118
• PF02350: Epimerase_2
  • amino acids 34 to 379 (346 residues), 338.7 bits, E=1.7e-105

Best Hits

Swiss-Prot: 44% identical to SACA_NEIMA: UDP-N-acetylglucosamine 2-epimerase (sacA) from Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

KEGG orthology group: K01791, UDP-N-acetylglucosamine 2-epimerase [EC: 5.1.3.14] (inferred from 100% identity to rru:Rru_A1493)

Predicted SEED Role

"UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14)" in subsystem CMP-N-acetylneuraminate Biosynthesis or Sialic Acid Metabolism (EC 5.1.3.14)

MetaCyc Pathways

• UDP-N-acetyl-α-D-mannosamine biosynthesis (1/1 steps found)
• CMP-N-acetylneuraminate biosynthesis II (bacteria) (1/3 steps found)
• CMP-N-acetylneuraminate biosynthesis I (eukaryotes) (1/5 steps found)
• superpathway of CMP-sialic acids biosynthesis (2/15 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.1.3.14

Use Curated BLAST to search for 5.1.3.14

Sequence Analysis Tools

See Q2RUA1 at UniProt or InterPro

Protein Sequence (384 amino acids)

>Rru_A1493 UDP-N-acetylglucosamine 2-epimerase (NCBI) (Rhodospirillum rubrum S1H)
MSLLSKKKQPTGAPLLVVIGTRPEAIKLAPVVLALRRNARVPVKVCLSGQHRDLLTQGLS
AFDLTIDHSLDLMTPDQRPSDLVARVITGLTPVIEATAPAWLVVQGDTTTALGAALAGFH
ARLDVAHVEAGLRSGDRAAPWPEEMNRRLIGQIAALHFAPTERARANLLAEGVAEGAIEV
TGNTVIDALHLALARIKDTPRVIEAAAPILATAGERALVLVTIHRRESLGEALPRLAEAL
LGLAKAEERLIVLPIHPNPRLAPLIEALSGHPGILLTPALDYLPFVALLHRADLILTDSG
GIQEEASALGKPVLVLRDTTERPELVAGGNGLVVGTRTARILDHALPLLTDPAARAALAQ
THDGFGDGHAAERIAQTLENRIAP