Protein Info for Rru_A1427 in Rhodospirillum rubrum S1H

Annotation: Carbon-monoxide dehydrogenase, catalytic subunit (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 639 TIGR01702: carbon-monoxide dehydrogenase, catalytic subunit" amino acids 10 to 639 (630 residues), 904.9 bits, see alignment E=1.1e-276 PF03063: Prismane" amino acids 48 to 620 (573 residues), 585.9 bits, see alignment E=3.7e-180

Best Hits

Swiss-Prot: 100% identical to COOS_RHORU: Carbon monoxide dehydrogenase (cooS) from Rhodospirillum rubrum

KEGG orthology group: K00198, carbon-monoxide dehydrogenase catalytic subunit [EC: 1.2.99.2] (inferred from 100% identity to rru:Rru_A1427)

MetaCyc: 100% identical to carbon monoxide dehydrogenase alpha subunit (Rhodospirillum rubrum)

Predicted SEED Role

"Carbon monoxide dehydrogenase CooS subunit (EC 1.2.99.2)" in subsystem Carbon monoxide induced hydrogenase (EC 1.2.99.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RUG7 at UniProt or InterPro

Protein Sequence (639 amino acids)

>Rru_A1427 Carbon-monoxide dehydrogenase, catalytic subunit (NCBI) (Rhodospirillum rubrum S1H)
MTHHDCAHCSSDACATEMLNLAEANSIETAWHRYEKQQPQCGFGSAGLCCRICLKGPCRI
DPFGEGPKYGVCGADRDTIVARHLVRMIAAGTAAHSEHGRHIALAMQHISQGELHDYSIR
DEAKLYAIAKTLGVATEGRGLLAIVGDLAAITLGDFQNQDYDKPCAWLAASLTPRRVKRL
GDLGLLPHNIDASVAQTMSRTHVGCDADPTNLILGGLRVAMADLDGSMLATELSDALFGT
PQPVVSAANLGVMKRGAVNIAVNGHNPMLSDIICDVAADLRDEAIAAGAAEGINIIGICC
TGHEVMMRHGVPLATNYLSQELPILTGALEAMVVDVQCIMPSLPRIAECFHTQIITTDKH
NKISGATHVPFDEHKAVETAKTIIRMAIAAFGRRDPNRVAIPAFKQKSIVGFSAEAVVAA
LAKVNADDPLKPLVDNVVNGNIQGIVLFVGCNTTKVQQDSAYVDLAKSLAKRNVLVLATG
CAAGAFAKAGLMTSEATTQYAGEGLKGVLSAIGTAAGLGGPLPLVMHMGSCVDNSRAVAL
ATALANKLGVDLSDLPLVASAPECMSEKALAIGSWAVTIGLPTHVGSVPPVIGSQIVTKL
VTETAKDLVGGYFIVDTDPKSAGDKLYAAIQERRAGLGL