Protein Info for Rru_A1304 in Rhodospirillum rubrum S1H

Annotation: Urocanate hydratase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 556 TIGR01228: urocanate hydratase" amino acids 10 to 553 (544 residues), 967.5 bits, see alignment E=9.8e-296 PF17391: Urocanase_N" amino acids 11 to 137 (127 residues), 203.9 bits, see alignment E=9.6e-65 PF01175: Urocanase" amino acids 140 to 349 (210 residues), 286.8 bits, see alignment E=1.6e-89 PF17392: Urocanase_C" amino acids 352 to 546 (195 residues), 301.8 bits, see alignment E=2.7e-94

Best Hits

Swiss-Prot: 100% identical to HUTU_RHORT: Urocanate hydratase (hutU) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 100% identity to rru:Rru_A1304)

MetaCyc: 78% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RUU0 at UniProt or InterPro

Protein Sequence (556 amino acids)

>Rru_A1304 Urocanate hydratase (NCBI) (Rhodospirillum rubrum S1H)
MSDRLDNQRVVRAPRGPEITCKSWLSEAPLRMLMNNLDPEVAEKPEELVVYGGIGRAARN
WQCYDQIVAALKRLEDDETLLVQSGKAVGVFKTHRDAPRVLIANSNLVPHWATWETFHAL
DRAGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRRHYGGSLAGRWILTGGLGGMGGA
QPLAATMAGASMLAVECQPSRIEARLRTGYLDRQTADLDQALAWIAEAGAPGAKPVSVGL
LGNAAEVFPELVKRGVRPDLVTDQTSAHDPLNGYLPAGWSLERWERGRERAPAEVIAAAK
ASMATQVRAMLAFHAQGIPTVDYGNNIRQRALEEGVSDAFAFPGFVPAYIRPLFCRGIGP
FRWAALSGDPEDIYRTDAKVKELIPDDPHLHTWLDMARERIHFQGLPSRICWVGLGDRHR
LGLAFNAMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTA
GGATWVSLHHGGGVGMGFSQHAGMVIVCDGSEDAARRIGRVLWNDPATGVMRHADAGYDD
AIACAREKGLDLPFLG