Protein Info for Rru_A1303 in Rhodospirillum rubrum S1H

Annotation: Imidazolonepropionase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 414 transmembrane" amino acids 250 to 266 (17 residues), see Phobius details amino acids 278 to 297 (20 residues), see Phobius details TIGR01224: imidazolonepropionase" amino acids 28 to 406 (379 residues), 468.3 bits, see alignment E=8.3e-145 PF01979: Amidohydro_1" amino acids 67 to 386 (320 residues), 62 bits, see alignment E=6.2e-21 PF07969: Amidohydro_3" amino acids 119 to 383 (265 residues), 52.4 bits, see alignment E=6.4e-18

Best Hits

Swiss-Prot: 100% identical to HUTI_RHORT: Imidazolonepropionase (hutI) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 100% identity to rru:Rru_A1303)

MetaCyc: 60% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RUU1 at UniProt or InterPro

Protein Sequence (414 amino acids)

>Rru_A1303 Imidazolonepropionase (NCBI) (Rhodospirillum rubrum S1H)
MAQAPWDSLWLNGSLATMAAGGAAYGAIEDGAIAVADGRLVFVGRRADLPPGAEDRAASL
HDLGGRWVTPGLIDCHTHLVYAGSRAREFELRLQGASYEEIARAGGGIVSTVGATRAASL
DQLIASALPRLDALLAEGVTTLEIKSGYGLTIESERRLLQAARALGRRRPVDVVTTFLGA
HALPPEFSGDGNGYIDHLCASMLPALAAEGLVDAVDVFCETIAFSLAQATRVFEAARGLG
LPVKVHAEQLGLLGGAALAAGFGALSADHVEYLDEAGVRALAAAGTVAVLLPGAFHMLRE
TQRPPVDALRRFGVAIAIATDCNPGTSPVTSPLLMLNMACVLFRLTPEEALAGLTRNGAK
ALGLSDRGVLAPGLRADFALWDIGHPAELAYALGLNPCHAVVRAGEPRPPRAPF