Protein Info for Rru_A1238 in Rhodospirillum rubrum S1H

Annotation: Gamma-glutamyl phosphate reductase GPR (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 21 to 294 (274 residues), 51.9 bits, E=2.4e-18
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 23 to 416 (394 residues), 451.7 bits, E=1e-139

Best Hits

Swiss-Prot: 100% identical to PROA_RHORT: Gamma-glutamyl phosphate reductase (proA) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 100% identity to rru:Rru_A1238)

MetaCyc: 43% identical to glutamate-5-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (3/3 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• L-N^δ-acetylornithine biosynthesis (4/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Sequence Analysis Tools

See Q2RV06 at UniProt or InterPro

Protein Sequence (427 amino acids)

>Rru_A1238 Gamma-glutamyl phosphate reductase GPR (NCBI) (Rhodospirillum rubrum S1H)
MNDAARLTTDDIPGLMIDIGRRARAAGRILALAPAAARNAALLAGAAALRAEAGAIALEN
AKDMSAGRAKGLTDALLDRLELTPARIEAMAKGLEDIAALPDPVGTVLAGWQRPNGLRIE
RVRVPIGVIGVIYESRPNVTADAGALCLKAGNAAILRGGSESFNSSRAIHRCLAAGLRAA
GLPEDAIQSVPTPDRAAVGMLLTMTDFIDVIVPRGGKSLIERVSAESKVPLFKHLEGLCH
TYIHAKADPQKALSVTVNAKMRRTGVCGSTETILVDRAIAATILPPLLDALAKAGCALRG
DEETRAFSERVGPATAEDWDTEYLDAIVSIRVVADLDEALAHIAAHSSDHTDCILTEDAA
AAERFLTEVDSAIVMHNASTQFADGGEFGMGAEIGISTGRLHARGPVGVEQLTIFKYKVR
GTGQTRP