Protein Info for Rru_A1213 in Rhodospirillum rubrum S1H

Name: kgd
Annotation: alpha-ketoglutarate decarboxylase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 987 PF16078: 2-oxogl_dehyd_N" amino acids 7 to 46 (40 residues), 60 bits, see alignment (E = 2.7e-20) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 9 to 964 (956 residues), 1146 bits, see alignment E=0 PF00676: E1_dh" amino acids 236 to 552 (317 residues), 182.5 bits, see alignment E=1.9e-57 PF02779: Transket_pyr" amino acids 621 to 814 (194 residues), 171.6 bits, see alignment E=2.6e-54 PF16870: OxoGdeHyase_C" amino acids 820 to 965 (146 residues), 175.3 bits, see alignment E=1.4e-55

Best Hits

Swiss-Prot: 61% identical to ODO1_BRUC2: 2-oxoglutarate dehydrogenase E1 component (sucA) from Brucella canis (strain ATCC 23365 / NCTC 10854)

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 66% identity to azl:AZL_025780)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RV31 at UniProt or InterPro

Protein Sequence (987 amino acids)

>Rru_A1213 alpha-ketoglutarate decarboxylase (RefSeq) (Rhodospirillum rubrum S1H)
MGDDVETSFLTGANAVYIAEVYSRYLADPSSVDPSWVAFFGELRDGAEELSGDLKGPSWT
SRGNAVIGTADPDAPAAAKAGKNGKAAAAPVPAAPAAAGLSTAEVRAHTLDSVRALMMIR
AYRVRGHLVADLDPLGLNKNNEHPELDYRSYGFTDADLEREIFIDNVLGMESATLRKIVE
VVRETYCGTIGVEFMHIQDPEQKSWIQRRIEGERNHTRFTPEGKRAILERLTEAEGFEKF
LQVKYTGTKRFGLEGGETVIPAIEQILKRGSQLGLTDINLGMAHRGRLNLLTSLLHKPYR
AIFSEFQGNSANPDDVQGSGDVKYHLGTSADREFDGAVVHLSLQANPSHLEAADPVVLGK
VRAKQTQLGDTDRKAVMALLIHGDAAFAGQGLVAECFGLSQLKGYRTGGTIHIVINNQIG
FTTSPQYSRSGQYCTDIAKMVQAPIFHVNGDDPEAVVHTARIVTEFRQEFGVDVVLDMVC
YRRHGHNESDEPAFTQPLMYDSIAHRQTTRTLYAQKLVSEGLISQAEADGLADAFTARLE
TEFQAATSYKPNRADWLAGKWEGLEALNGEEEFRQDRTEVPAEVLRRVGTALSTPPENFD
TNRKILRQMKAKAEMLETGQGIDWATAEALAFGTLLLEGTRVRLSGQDSGRGTFSHRHSV
LIDQTNENRHIPLDHLDPAQARFEVIDSPLSEFSVLGFEYGYSLAEPKALVLWEAQFGDF
ANGAQVIFDQFISSAESKWLRMSGLVCLLPHGYEGQGPEHSSARPERYLQLCAEDNMQVV
NITSPANYFHALRRQVHRNFRKPLIVMAPKSLLRHKLAVSPLSDFTDHGFRRVLPETKTL
VEDDKITRVVLCSGKVYYDLYQAREDQGIDDVAIVRIEQLYPWPKDTLMKVLKRYPNADV
VWCQEEPANMGYWTFVDRRIEFFLQELEHRPGRASYAGRPAAASPATGSNRGHGREQALL
VEQALTWKRDVLPQPFRRATKLSIIGQ