Protein Info for Rru_A1071 in Rhodospirillum rubrum S1H

Annotation: Adenylate/Guanylate Cyclase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 680 transmembrane" amino acids 119 to 139 (21 residues), see Phobius details amino acids 160 to 182 (23 residues), see Phobius details PF00211: Guanylate_cyc" amino acids 489 to 645 (157 residues), 47.9 bits, see alignment E=6.2e-17

Best Hits

KEGG orthology group: K01768, adenylate cyclase [EC: 4.6.1.1] (inferred from 100% identity to rru:Rru_A1071)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RVH3 at UniProt or InterPro

Protein Sequence (680 amino acids)

>Rru_A1071 Adenylate/Guanylate Cyclase (NCBI) (Rhodospirillum rubrum S1H)
MASMTHYEVYLMELRGDWSLQQRYVSSERQEAIDEAKRLEAELNLPTKVVRELFNPQSGM
AEEQVVYISPKARELRERAMRRAGPHAAGGGPDSWVSSRGEKAKAKGKAPATSLSDLMAR
MILVVTASLILAGIGGWLAPSLLSALSLTTGGGPASGNMRGVMVGVFLFLFTVSFLVIGR
KLIPYAEILSRPKKTKPIEEAIGQRPDMAPGAHLAPPPKAATSEEALSSIDPVALMEDMG
PIPVPPPPTEPEQKIPAAQSRKARKKAAEARAAEEEAERRRRENQDFQEHDAREMAAREK
EKRAKEAEARKAAEKEAEDKAAAEKEAEEKAAEQAKAAETLAAEDIASEPPASSPEQDRL
RLTALSFLGEMVAALKVSHPQLDVYDRFGINLFLAGACETLVAGNDLSGSAKPALLREML
GVMGTRPALALMFSDKLDEYLMEPRYMQMLQAGRQAMGMKLAGGGEPFAPLPQLMADWRA
PQAARPATASTVAIVFTDMVGSTDINARFGDRHSHEITRVHNAIVRAALGRFDGREVKHT
GDGIMATFPVVSQAVEAMIEVQKALAEHNRIAPDLRLDLRVGINAGEPLVDENDYHGLSV
TLAARLCAQAQGGEVLCSGVVRDLAQGKDLTFRDRGQVMLKGIGEPQRLFEAVWRDADAP
SPPPPPPPPAEEPAAFKETP