Protein Info for Rru_A0656 in Rhodospirillum rubrum S1H

Annotation: delta-1-pyrroline-5-carboxylate dehydrogenase 3 (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1236 PF14850: Pro_dh-DNA_bdg" amino acids 59 to 172 (114 residues), 143.4 bits, see alignment E=6e-46 PF01619: Pro_dh" amino acids 188 to 474 (287 residues), 328.5 bits, see alignment E=5.9e-102 TIGR01238: delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 510 to 1002 (493 residues), 685.2 bits, see alignment E=2.4e-210 PF00171: Aldedh" amino acids 561 to 1001 (441 residues), 359.4 bits, see alignment E=3.8e-111

Best Hits

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 100% identity to rru:Rru_A0656)

Predicted SEED Role

"Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88)" in subsystem Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.2.1.88, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.88 or 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RWN5 at UniProt or InterPro

Protein Sequence (1236 amino acids)

>Rru_A0656 delta-1-pyrroline-5-carboxylate dehydrogenase 3 (NCBI) (Rhodospirillum rubrum S1H)
MSDLASLRLSLRREPLRDEAAVVADRLAALPLDADRRQAVSEAGRALVERMRASGEVTMM
DNMLAEYGLSTDEGVALMCLAEAYLRVPDAPTLDALIKDKIGGRDWAEHAGESGSMLVNA
STWGLMFTGRLYGESWAEDTLLGSVRKMVRRVGEPVVRTAVAQCMKIMGAQFVLGRTIDE
AWRNGGPLIEKGYTYSFDMLGEAARTAADATHYFKAYANAIAAVGARATQADVHANSGIS
VKLSALHPRYEEVNRARVMAELVPRLSALAEMAAAVNVGMTVDAEEADRLDLSLSVMEAV
LRNPNLAGWGGFGIVVQAYLKSTLPTIDWIIALARDLDRQLAVRLVKGAYWDAEIKTAQS
LALPAYPVFTRKASTDVSYMASAARLLGAQDHIYPMFAGHNAHTASAVLEMAGPDAVFEF
QRLHGMGETLHELLRRDHGHRCRIYAPVGVHKDLLAYLVRRLLENGANSSFVNQALDKDV
PAAELTRDPATVVAQASSVAHAGIPLPPALFGAERANSKGWNLNNPLMAAELDERLTPFR
AARWSAAPMIGATPPRSGGEAVTNPADRDETVGFVVSATANDVTVALETTTRAFPNWRDR
APAERAALLDRIAALYEEHAPELIALLSREAGKTRWDGILEVREAVDFCRYYAARSRADL
AGSGRKGRGVFVCISPWNFPLAIFTGQIAAALVSGNTVIAKPAEQTPLIAARAVALMREA
GVPPEVLALLPGEGASVGAALTASPLVAGVCFTGSTETAIAIDRAQASAGTGGAPLIAET
GGLNAMIVDSTALPEHAVRDIVAGAFQSAGQRCSALRALFVQEDIADHLLTMLAGAVQEL
VVGNPWEAVTDVGPVIDAEAKAVITRHCEALTAAGRRLFVHDKAKAAKGGGFVAPVAFSL
DRFEDLKSEIFGPVLHVIRFRNTEIDAVVDSINAAGYGLTLGIHSRVDAQVERICSRARV
GNIYVNRNQIGAVVGVQPFGGEGLSGTGPKAGGPGYLERFTIAAPVALPEVALPASHGED
AAAENALDAARWAASVQPAWDGRSDRLAILEAALRALPEAARPTASAVLDLAKPLVAPPL
DLVGVTGESNRLALHGRGVVLCLGGGERPATALLAQALLGLAAGNAVLLAGDPGAGVIAA
LRKALAEAGLSAGLVQSIVASDLPGLLREMPRLALVAHEGGVGGEGLRVALAARSGARVP
LVALVDGVGRYVSERVVSIDTTASGGNASLLMLDEG