Protein Info for Rru_A0556 in Rhodospirillum rubrum S1H

Annotation: Formyltetrahydrofolate deformylase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 55% identical to PURU_CORS1: Formyltetrahydrofolate deformylase (purU) from Corynebacterium sp. (strain P-1)

KEGG orthology group: K01433, formyltetrahydrofolate deformylase [EC: 3.5.1.10] (inferred from 100% identity to rru:Rru_A0556)

Predicted SEED Role

"Formyltetrahydrofolate deformylase (EC 3.5.1.10)" in subsystem One-carbon metabolism by tetrahydropterines (EC 3.5.1.10)

MetaCyc Pathways

formaldehyde oxidation VII (THF pathway) (4/4 steps found)
folate transformations I (8/13 steps found)
purine nucleobases degradation I (anaerobic) (6/15 steps found)
purine nucleobases degradation II (anaerobic) (12/24 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RWY5 at UniProt or InterPro

Protein Sequence (297 amino acids)

>Rru_A0556 Formyltetrahydrofolate deformylase (NCBI) (Rhodospirillum rubrum S1H)
MLQPQTPPPPTDPRKAIILTITCPDGFGLVAAVSGFLNSQGAFIIEAAYYSDPDTGRFFM
RTVFRSDTAGLPSLGALRECFAPVAERFEMTWDLVSAERKPKVVIAVSRFGHCLYDLLHR
WQAGQLHVEIPAIVSNHKDLARLAEWHGIPFHHLPVTTGGKEAQEEAILKVIDDSSADLV
VLARYMQILSPAMSSALSGRCINIHHSFLPSFKGAKPYHQAHARGVKIIGATAHYVTDAL
DEGPIIEQEVARVDHKYRVDDLVAAGRDLETVVLARAVRWHVERRVMINGTKTVVLR