Protein Info for Rru_A0429 in Rhodospirillum rubrum S1H

Annotation: Guanylate kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03263: guanylate kinase
  • amino acids 16 to 194 (179 residues), 225.9 bits, E=1.4e-71
• PF00625: Guanylate_kin
  • amino acids 17 to 195 (179 residues), 162.9 bits, E=3.5e-52

Best Hits

Swiss-Prot: 100% identical to KGUA_RHORT: Guanylate kinase (gmk) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K00942, guanylate kinase [EC: 2.7.4.8] (inferred from 100% identity to rru:Rru_A0429)

MetaCyc: 50% identical to guanylate kinase (Escherichia coli K-12 substr. MG1655)
Guanylate kinase. [EC: 2.7.4.8]; T(2)-induced deoxynucleotide kinase. [EC: 2.7.4.8, 2.7.4.12, 2.7.4.13]

Predicted SEED Role

"Guanylate kinase (EC 2.7.4.8)" in subsystem MLST or Purine conversions (EC 2.7.4.8)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (9/9 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (8/9 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (11/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (5/7 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)
• dZTP biosynthesis (3/5 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (5/8 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (4/7 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (4/9 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.12 or 2.7.4.13 or 2.7.4.8

Sequence Analysis Tools

See Q2RXB1 at UniProt or InterPro

Protein Sequence (218 amino acids)

>Rru_A0429 Guanylate kinase (NCBI) (Rhodospirillum rubrum S1H)
MSAPSSAPALIPRRGMMLVLSSPSGAGKTTISRALLAEEDGLEMSVSVTTRAPRPGERDG
EHYHFIDVARYMALTKDDGLLEHARVFENYYGTPRAPVEAALARGCDVLFDIDWQGTQQV
AEKARTDLVSIFILPPSVGELERRLKGRAQDSDAVVAARMAKAMDEISHYFEYDYIIVND
DLDRSIADVRAILRAERLKRARRIGLAEFVNRMRGAGE