Protein Info for Rru_A0404 in Rhodospirillum rubrum S1H

Annotation: Amidophosphoribosyl transferase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01134: amidophosphoribosyltransferase
  • amino acids 22 to 468 (447 residues), 531.3 bits, E=1.3e-163
• PF13522: GATase_6
  • amino acids 86 to 215 (130 residues), 75.3 bits, E=7.3e-25
• PF13537: GATase_7
  • amino acids 102 to 219 (118 residues), 76.2 bits, E=3.3e-25
• PF00156: Pribosyltran
  • amino acids 291 to 391 (101 residues), 34.7 bits, E=1.6e-12

Best Hits

Swiss-Prot: 54% identical to ASE1_ARATH: Amidophosphoribosyltransferase 1, chloroplastic (ASE1) from Arabidopsis thaliana

KEGG orthology group: K00764, amidophosphoribosyltransferase [EC: 2.4.2.14] (inferred from 100% identity to rru:Rru_A0404)

Predicted SEED Role

"Amidophosphoribosyltransferase (EC 2.4.2.14)" in subsystem De Novo Purine Biosynthesis (EC 2.4.2.14)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (5/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (4/5 steps found)

KEGG Metabolic Maps

• Glutamate metabolism
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.14

Sequence Analysis Tools

See Q2RXD6 at UniProt or InterPro

Protein Sequence (488 amino acids)

>Rru_A0404 Amidophosphoribosyl transferase (NCBI) (Rhodospirillum rubrum S1H)
MAPTDIDFSTDPFDDDKLREECGVFGVFADPNAASHTALGLHALQHRGQEAAGIVTFDGT
QFHSVKGPGHVSENFKSETVISQLVGSSAIGHVRYSTTGGAVMRNIQPLFAEFAFGGLAI
AHNGNLTNAMTLRERLVQRGCLFQSTSDTEVIVHLIAISICSSVEDRIIDALRQVQGAYS
IVALTNNALIGVRDPMGIRPLVLGQLDGAYIFASETCALDIIGADYIRDVEPGELIIITG
KEVRSLRPFPQTPSHFCVFEYIYFARPDSIVEERSVYEVRKAIGRELARESAVEADVVVP
VPDSGVPSALGYAAEAGLPFEYGIIRNHYVGRTFIQPTDKTRNLGVKRKHNPNRSQLEGK
RVILVDDSIVRGTTSTKIVEMVRQAGAREVHMRISSPPTAYPCFYGIDTPEREKLLAANY
SVEDMAKLLGVDSLAFVSLDGLYRAAGVESRNAERPQFCDACFSGHYPVPNQDRAQKSHP
LQLALLND