Protein Info for Rru_A0228 in Rhodospirillum rubrum S1H

Annotation: Twin-arginine translocation pathway signal (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF00144: Beta-lactamase" amino acids 46 to 289 (244 residues), 119.4 bits, see alignment E=1.9e-38 PF13354: Beta-lactamase2" amino acids 56 to 271 (216 residues), 167.1 bits, see alignment E=4e-53

Best Hits

Swiss-Prot: 49% identical to BLAC_PROMI: Beta-lactamase (blaP) from Proteus mirabilis

KEGG orthology group: K01467, beta-lactamase [EC: 3.5.2.6] (inferred from 100% identity to rru:Rru_A0228)

MetaCyc: 44% identical to PSE-4 beta-lactamase (Pseudomonas aeruginosa)
Beta-lactamase. [EC: 3.5.2.6]

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RXW2 at UniProt or InterPro

Protein Sequence (300 amino acids)

>Rru_A0228 Twin-arginine translocation pathway signal (NCBI) (Rhodospirillum rubrum S1H)
MRKTVTRRDFSVLIGSLVASGLIAPAAIGQEAGPAEDALTARLIETEQRLGARLGATILD
THTGRNWRYRAGERFPLCSTFKVIACGALLARVDAGTEDLSQRVTFPESAVVAYSPVTKG
RGEAGMTLAEICEAAITRSDNTAGNILLDRLGGPAGVTTFARALGDTTTRLDRRETDLNE
ATPGDPRDTTTPEAMAKLMATLVLGKGLSVTSRDRLTNWLLANKTGEAKLRAGLPKDWRI
GDKTGGGDHGTMNDVAVVWPPGRQPLIIALYMTQTTASFEDRNRAIADIGRTLAAVVTQP