Protein Info for Rru_A0104 in Rhodospirillum rubrum S1H

Annotation: Alpha-2-macroglobulin-like protein (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1759 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details PF21142: A2M_bMG2" amino acids 293 to 393 (101 residues), 36.4 bits, see alignment 1.9e-12 PF11974: bMG3" amino acids 416 to 517 (102 residues), 89.3 bits, see alignment 5.8e-29 PF01835: MG2" amino acids 523 to 618 (96 residues), 86.5 bits, see alignment 5.5e-28 PF17972: bMG5" amino acids 645 to 754 (110 residues), 78.3 bits, see alignment 2.9e-25 PF17962: bMG6" amino acids 762 to 874 (113 residues), 103.1 bits, see alignment 4e-33 PF07703: A2M_BRD" amino acids 888 to 1030 (143 residues), 79.9 bits, see alignment E=9.8e-26 PF00207: A2M" amino acids 1094 to 1170 (77 residues), 31.1 bits, see alignment (E = 6.7e-11) PF17973: bMG10" amino acids 1609 to 1743 (135 residues), 54 bits, see alignment 8.2e-18

Best Hits

KEGG orthology group: K06894, (no description) (inferred from 100% identity to rru:Rru_A0104)

Predicted SEED Role

"PAN domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RY86 at UniProt or InterPro

Protein Sequence (1759 amino acids)

>Rru_A0104 Alpha-2-macroglobulin-like protein (NCBI) (Rhodospirillum rubrum S1H)
MGLSLRAFGALPGRARRLGIATLFGLIALVLALPLVARAADPVASDAATAQALADLGREA
EGLKANVLYVVENDGQRAQAKAAEARGKAERGEWDGAVDAWEQALRAGLKQADRWLILAD
FYDKAEGAEPRAVAAAFLAIAEAAGGEARALAQTRTAELLMAAERDDVALALFRRAQASH
PTPRAANGIAALGGTGLAIRRTLVEADRDLPRLCLDLTAAPAAIDLAPYVKIEPAVPVAV
SATGKRLCIDGLPHGQTVGVTLREGLPTLTGATLARSLTLEARIANRAPRVAFAGNAYIL
PARGARDVAVRTVNVDQLWLTLLRVNDRGLAGLLRDHDLNSMVSGGDLRDIAEDSGEKIW
EGKLDIDAALNRETATAIPLATILPDPRPGLYLLAAEDRLRGSTPWWNQPSQWLLVTDIG
LQSAVGLDGLSVFARSLSSGRALVGASVTLVARNNAEVASAVTDRNGMVRFQPAQLSGRD
GKTPTWVMVYGPAGDFAYLDVTGPAFDLSDRGVGGREAPGPLDAFLYTERGIYRPGETVH
LAGLLRDSGARGLSGLPLTVKILRPDGVQVDRQVLSDQGVGAYGADIPLLKEARSGRWEI
TAHVDPAAPPIGRVSFVVEDFVPQTMEVTLKTTATALDLTTGEPSAATASVAVQADYFYG
APVASQPVTSEVVLSADPEPFAAFKGFTFGLAQEEVEPRRFDLEPTLTNAKGAATLAVAL
DGAPDTSHPLRALVRTSVIDAGGRGAARTLVLPVRHQPMAVGIKARFEGDSLAEGATPAF
DLAAVNPAGAPVGQRPLDWVLYEEVSRYTWYENGGAWNYRRTVSDEVRASGRVMTAANGL
AEVAVPVGFGAFRLEVSDGGGSLAASSQRFRAGWWVAGSDSRDTPDTLKVTREAEAYRPG
ERARLRLEAPFAGHALVSVVTDRLLDVLDVPLPEGGLTVELPVTEAWGVGAYVVVTAFRP
GENAGLRGPGRAMGVAWVPVDMTRRTLSVALEAPQTVLPRQRLEVPVQVAGGQGPVFLTL
AAVDEGILQLTDFQSPDPVAYYYGKRSLGLAYRDAYGRLLEGTNARPGRLREGGDASGRH
LMGLPRSSVETVSLFSGIVAVGKDGRALVPVDIPDFTGRLRLMAVAFSGAGVGHGEAAVT
VRDPMVAMATLPRFLAPGDRSFLSVSLDNIDGPAGVWTLAAVGEGALSVPEGPRAVDLAK
GGRDLVRLAVEGLNPGPGTLRLAITAPTGERREKTWSFDVRPGAPRMTLAHRLDLGGHGR
ARLDGGLLEGFFRQGVEGTLTLSSVPNLDPIGNASALRAYPYGCLEQTVSRAWVALYGHD
LDTPALWKGWSGKDVLATEIARVIALQRPDGGFALWSSSGGLDPWLSAYALEFLLRAREE
KAAVPDFVVERGLAYLDDAIADGDFSDAGLPAAAYAHYVLARAGAMDLGRLRYFADTYLA
RMPTPLARVQTAAALSLLGDGPRAVAALKQGLGDRARLVSDRDDWDYGSALRDRAATLAL
GIETGLLGDDALATADTLADTLARTPHPSTQERGWLVLAARALARQQGSVAATVDGVGVD
SGRTTVTLPLSIQDLGEGVDIVNGGDRALRVVASLDGQPEAPPPAASEGLTIDRRFLTLA
GEAVDPTKVRQNDLLVALITGSATDPKVIARERGNRLLVVDLLPAGVEIENPRIGAGAPG
SEGLSWLPELTDTTHVEARDDRYVASVDIDAKTPTFTLAYVVRAVSPGSFVVPGAAVEDM
DRPALRANQGAGRLSIAAR