Protein Info for Rru_A0098 in Rhodospirillum rubrum S1H
Annotation: Cystathionine gamma-synthase (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01739, cystathionine gamma-synthase [EC: 2.5.1.48] (inferred from 100% identity to rru:Rru_A0098)Predicted SEED Role
No annotation
MetaCyc Pathways
- aspartate superpathway (23/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (9/10 steps found)
- L-methionine biosynthesis II (5/6 steps found)
- superpathway of L-cysteine biosynthesis (fungi) (5/6 steps found)
- superpathway of S-adenosyl-L-methionine biosynthesis (7/9 steps found)
- superpathway of L-methionine biosynthesis (transsulfuration) (7/9 steps found)
- superpathway of L-homoserine and L-methionine biosynthesis (6/8 steps found)
- homocysteine and cysteine interconversion (3/4 steps found)
- L-methionine biosynthesis I (3/5 steps found)
KEGG Metabolic Maps
- Biosynthesis of plant hormones
- Cysteine metabolism
- Methionine metabolism
- Selenoamino acid metabolism
- Sulfur metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.5.1.48
Use Curated BLAST to search for 2.5.1.48
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q2RY92 at UniProt or InterPro
Protein Sequence (403 amino acids)
>Rru_A0098 Cystathionine gamma-synthase (NCBI) (Rhodospirillum rubrum S1H) MKPGPFPPLAQATLALHAGTTDESDGAQVLNPLVPATSFFTKPEAVGFSANDMAEDTPFL YTRWNNPTNALLEERLAALEGGEAAVVFASGMAALSGLFLSQLKAGDHLVISSVCYAGLA EVAHDILPGLGIATTAVDTSNLEAVRAALRPETRLIHIETPGNPILRLSDIEALAAIAHA HGALLSVDSTMATPIATRPLALGADFVAHSLTKYACGHGDALGGAIIGKAQAMAALRKHA LIHFGGAISPFAAWLILRGLETLSLRMAGHQAGAAAVAAYLEGHPRLRRVLWPGLPSHPQ HALACRQMKNFSGMVSFSADDGPALARQLAERLQVISYAVSLGKTRSLLFYIPTEALIAS SFHLDGDDARSYRDWTGDGTFRLSVGLEDPADLIADLERALAP