Protein Info for Rru_A0051 in Rhodospirillum rubrum S1H

Annotation: Carboxyl transferase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 517 PF01039: Carboxyl_trans" amino acids 30 to 515 (486 residues), 572.7 bits, see alignment E=6.7e-176 PF03255: ACCA" amino acids 343 to 449 (107 residues), 46.7 bits, see alignment E=2.6e-16

Best Hits

Swiss-Prot: 54% identical to 12S_PROFR: Methylmalonyl-CoA carboxyltransferase 12S subunit from Propionibacterium freudenreichii subsp. shermanii

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A0051)

MetaCyc: 54% identical to methylmalonyl-CoA carboxyltransferase 12S subunit (Propionibacterium freudenreichii shermanii)
Methylmalonyl-CoA carboxytransferase. [EC: 2.1.3.1]

Predicted SEED Role

"Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)" in subsystem Na+ translocating decarboxylases and related biotin-dependent enzymes or Propionyl-CoA to Succinyl-CoA Module (EC 4.1.1.41)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.3.1 or 4.1.1.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RYD9 at UniProt or InterPro

Protein Sequence (517 amino acids)

>Rru_A0051 Carboxyl transferase (NCBI) (Rhodospirillum rubrum S1H)
MAISKTLVDELEKRRAIALEGGGADKAAARHAKGRLTARERLMALYSPGTFQEFGLHALH
NTRHFGMENKPIPADGVIVGTGFVDGRPVAGFSQDFTVAGGSLGEIHARKICHTLDHAVK
AGIPVVGFQDSGGARIQEGVGALSAYGQVFYRNVQLSGVVPQIAVIAGPCAGGAAYSPAL
MDFVIMTRENAQMFICGPEVIRAVTGQSTTVDEIGSAQVHASVSGNIHFIAESDDHAVAI
AHRLLSFLPSNNMSDPPHTIEPDLSIDDDPGFDDLLPADSKTPFDVREVILRLSDGGDFM
EVMADFAANIVIGFGRIGGVVVGYVANQPLVKAGTLDIDASDKAARFVRFCNIFNIPLVT
LVDVPGFLPGVMEERRGIIRHGAKMLFAYASATVPKITVILRKAYGGAYLAMCSQDMGAD
RVLAWPSAEIAVMGAEGAVSILYNKELAQAEDRQARARELADDYRAEFASPYLSAGMLFV
SDIIQPRQTRSAVALTLRGLLSKRETRPPKKHGNIPL