Protein Info for Xcc-8004.5221.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: D-mannonate oxidoreductase (EC 1.1.1.57)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 PF01232: Mannitol_dh" amino acids 50 to 206 (157 residues), 130.3 bits, see alignment E=7e-42 PF08125: Mannitol_dh_C" amino acids 234 to 467 (234 residues), 205.2 bits, see alignment E=1.2e-64

Best Hits

Swiss-Prot: 41% identical to M2DH_ASPFC: Mannitol 2-dehydrogenase (AFUB_071700) from Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)

KEGG orthology group: K00040, fructuronate reductase [EC: 1.1.1.57] (inferred from 100% identity to xca:xccb100_4312)

Predicted SEED Role

"D-mannonate oxidoreductase (EC 1.1.1.57)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.57)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.57

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H2XCP3 at UniProt or InterPro

Protein Sequence (506 amino acids)

>Xcc-8004.5221.1 D-mannonate oxidoreductase (EC 1.1.1.57) (Xanthomonas campestris pv. campestris strain 8004)
VRVRPPSELASPHDFKQTPMPIPTLSIATLAHLPATVLTPTYTPKHTTIGIVHLGAGAFH
RAHQAVYIDDLLADDPAWAICAVSLHNPQVRDALRPQDGLYTLALLDAQPQLRVIGAIAE
VLCASDEQPAVLARLADPAVRLVTLTVTEKGYCLAGDALDLSHPDIVHDLAHPQTPRSAI
GYLVAGLYARRQHGRAPFTVLSCDNLADNGSLLRRATVLLAQQRDPALAAWIEQHVSFPR
SMVDSITPATDEALRAQVHAQTGLHDAWPIQREHYTQWVIEDRFCNGRPAFERAGVTLSD
DIAGYARAKLRLLNGPHSALAYLGSLLQLETVADAMQHTPLASFVATLMREDIGPSLATM
PGFDPHRYSDAILARFRNPAIRHLLAQIAWDGSQKIPVRLLGTIADALTAGRRIDRLCLP
VAAWLHFVRRQAHAGVALVDPLGEQLSAIGRIATGDAHRDIAAFLTVDATFAPLSADERF
VEALQQAYALFQTARPADVQQLLATA