Protein Info for Xcc-8004.4567.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01128: IspD
  • amino acids 6 to 120 (115 residues), 33.7 bits, E=8.2e-12
• TIGR01173: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase
  • amino acids 6 to 454 (449 residues), 612.4 bits, E=2.6e-188
• PF00483: NTP_transferase
  • amino acids 7 to 211 (205 residues), 40.5 bits, E=6.2e-14
• PF12804: NTP_transf_3
  • amino acids 7 to 129 (123 residues), 81.8 bits, E=1.6e-26
• PF00132: Hexapep
  • amino acids 394 to 428 (35 residues), 34.4 bits, 3e-12
• PF14602: Hexapep_2
  • amino acids 394 to 428 (35 residues), 35.5 bits, 1.6e-12

Best Hits

Swiss-Prot: 100% identical to GLMU_XANC8: Bifunctional protein GlmU (glmU) from Xanthomonas campestris pv. campestris (strain 8004)

KEGG orthology group: K04042, bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC: 2.3.1.157 2.7.7.23] (inferred from 100% identity to xcb:XC_3674)

Predicted SEED Role

"N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)" in subsystem Peptidoglycan Biosynthesis or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.3.1.157, EC 2.7.7.23)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (11/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (5/7 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (6/9 steps found)
• peptidoglycan recycling I (9/14 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.157 or 2.7.7.23

Sequence Analysis Tools

See Q4UQF8 at UniProt or InterPro

Protein Sequence (454 amino acids)

>Xcc-8004.4567.1 N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) (Xanthomonas campestris pv. campestris strain 8004)
MTLPLHVVILAAGEGKRMRSALPKVLQPLAGQPMLAHVIATARELQPAAIHVVHGHGGAQ
VQAAFAGQPDLQWAEQRQQLGTGHAVQQALHAVPDAATVLVLYGDVPLIRSESLRELLHA
PGRIAVLVADLANPSGYGRIVRNPEGKVAAIVEQKDADDEQRRIRTINTGILTAESTALR
RWLGGLSNDNAQGEFYLTDVFASAAADYTPADMVQVSDPQDVEGANDPWQLAQLERAWQL
RAARALCLQGVRMADPARVEQRGRVQVGHDVQLDIDVILEGEVTLGDGVVIGPFVRLRDV
QLAAGTQVRAHCDLEGVVTEGAVQIGPFARLRPGTVLADGVHIGNFVETKKVVMGAGSKA
NHLTYLGDAVVGSKVNIGAGTITCNYDGVNKSQTTIGDGAFVGSNSALVAPIEIGTGATI
GAGSVITRDAPPHQLSVARPRQTVIEGWERPKKK