Protein Info for Xcc-8004.318.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 680 PF00289: Biotin_carb_N" amino acids 20 to 128 (109 residues), 154.2 bits, see alignment E=5.7e-49 PF02786: CPSase_L_D2" amino acids 133 to 341 (209 residues), 247.1 bits, see alignment E=4.8e-77 PF07478: Dala_Dala_lig_C" amino acids 159 to 309 (151 residues), 35.6 bits, see alignment E=2.5e-12 PF02222: ATP-grasp" amino acids 161 to 310 (150 residues), 37.2 bits, see alignment E=8.4e-13 PF02785: Biotin_carb_C" amino acids 354 to 461 (108 residues), 121.1 bits, see alignment E=8e-39 PF21139: MCC_alpha_BT" amino acids 477 to 579 (103 residues), 34.9 bits, see alignment E=5.1e-12 PF00364: Biotin_lipoyl" amino acids 610 to 674 (65 residues), 47.2 bits, see alignment E=5.5e-16

Best Hits

KEGG orthology group: K01968, 3-methylcrotonyl-CoA carboxylase alpha subunit [EC: 6.4.1.4] (inferred from 100% identity to xcc:XCC0244)

Predicted SEED Role

"Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism or Serine-glyoxylate cycle (EC 6.4.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.4

Use Curated BLAST to search for 6.4.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H2X364 at UniProt or InterPro

Protein Sequence (680 amino acids)

>Xcc-8004.318.1 Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4) (Xanthomonas campestris pv. campestris strain 8004)
MTQHDMPQHASITGKGQPYFDKVLIANRGEIACRVIATCRRLGIATVAVYSDADRDARHV
RLADEAIHIGASPAQQSYLRGDAILAAARASDAQAIHPGYGFLSENAGFADACAQAGVVF
IGPPAQAIRAMGDKSAAKALMQRAGVPLTPGYHGDEQAPAFLRAQADAIGYPVLIKASAG
GGGKGMRRVDASAAFEDALASCQREAQSAFGNAHVLVEKYVERPRHIEIQVFADTHGAVV
HLFERDCSVQRRHQKVLDEAPAPGMTEQRRAAMGKAAVDAARAVGYVGAGTVEFIAGPDG
DFYFMEMNTRLQVEHPVTELITGTDLVDWQLRVAAGLPLPKRQDELRIHGHALEARLYAE
DADRGFLPSTGTLRQLRLPAASAHVRIDAGVEQGDTISPYYDPMIAKLIVWDHDRPAALA
RMRDALAHCHAIGVTTNSAFLARLVSTQAFATADLDTGLIEREQAALFPAPQPPPMAWWC
LAAVLVAEAAPHAAADPADPFSPWQLADGWRIGAHAARTLVLEAAGERRTLAVRPTADGW
QVDSADQTHTLRYHAHGEHLRVDMDGRQWRAQILRDGTAITVLSGAQRAHFQHHDALVEA
EQPAQAEGGLTAPMPGRVVALVAPLGEPVRRGQALVVLEAMKMEHTLHAPADGTVQAYLV
AEGDLVADGVALVEFVSASA