Protein Info for Xcc-8004.2943.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00735: imidazoleglycerol phosphate synthase, cyclase subunit
  • amino acids 1 to 255 (255 residues), 339.3 bits, E=6.2e-106
• PF00977: His_biosynth
  • amino acids 5 to 238 (234 residues), 240.5 bits, E=1.7e-75
• PF01207: Dus
  • amino acids 21 to 115 (95 residues), 26.4 bits, E=3.8e-10

Best Hits

Swiss-Prot: 100% identical to HIS6_XANCP: Imidazole glycerol phosphate synthase subunit HisF (hisF) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

KEGG orthology group: K02500, cyclase [EC: 4.1.3.-] (inferred from 100% identity to xca:xccb100_2101)

MetaCyc: 64% identical to imidazole glycerol phosphate synthase subunit HisF (Escherichia coli K-12 substr. MG1655)
GLUTAMIDOTRANS-RXN [EC: 4.3.2.10]

Predicted SEED Role

"Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)" in subsystem Histidine Biosynthesis (EC 4.1.3.-)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• L-histidine biosynthesis (10/10 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (3/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (3/4 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• L-glutamate and L-glutamine biosynthesis (4/7 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.- or 4.3.2.10

Sequence Analysis Tools

See Q4UU45 at UniProt or InterPro

Protein Sequence (258 amino acids)

>Xcc-8004.2943.1 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) (Xanthomonas campestris pv. campestris strain 8004)
MLSRRIIPCLDVRDGRVVKGVKFRDHIDMGDIVELAMRYRDQGADELVFYDIGASPEGRS
VDYAWVERVARLIDIPFCVAGGIRDVETARAVLHAGADKISINSPALGRPQLISELADAF
GVQCVVVGIDSIREEDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQRLGAGEIVLNCMDN
DGVRHGYDIAQLRQVRALCRVPLIASGGAGEMQHFADVFDQADADGALAASVFHSGAIPI
PELKRFLRAQQIEVRDGQ