Protein Info for Xcc-8004.2923.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00682: HMGL-like
  • amino acids 5 to 275 (271 residues), 169.7 bits, E=4.9e-54

Best Hits

Swiss-Prot: 60% identical to HMGCL_CHICK: Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) from Gallus gallus

KEGG orthology group: K01640, hydroxymethylglutaryl-CoA lyase [EC: 4.1.3.4] (inferred from 100% identity to xca:xccb100_2120)

MetaCyc: 59% identical to hydroxymethylglutaryl-CoA lyase subunit (Pseudomonas aeruginosa PAO1)
Hydroxymethylglutaryl-CoA lyase. [EC: 4.1.3.4]; 3-hydroxy-3-isohexenylglutaryl-CoA lyase. [EC: 4.1.3.4, 4.1.3.26]

Predicted SEED Role

"Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism (EC 4.1.3.4)

MetaCyc Pathways

• L-leucine degradation I (5/6 steps found)
• mevalonate degradation (1/2 steps found)
• ketogenesis (3/5 steps found)
• cis-geranyl-CoA degradation (2/9 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Geraniol degradation
• Synthesis and degradation of ketone bodies
• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.26 or 4.1.3.4

Sequence Analysis Tools

See A0A0H2X854 at UniProt or InterPro

Protein Sequence (298 amino acids)

>Xcc-8004.2923.1 Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) (Xanthomonas campestris pv. campestris strain 8004)
MSDFVRIVEVGPRDGLQNEANPIASADKIALINQLSATGLRTIEATSFVSPRWVPQLADA
AEVFAGITRQPGIAYPVLVPNLQGYARAHAAGAQEVAVFTAASETFNRTNTNAGIDESIE
RFRPILAQAAQDGVRVRGYVSTVLGCPYQGEVAVADVVNVAERLYRLGCYEISLGDTIGV
GTPAKARQMLAAVAGSIPLQALAVHFHDTYGQALANIAACLEQGVRVVDAAVSGAGGCPY
AKGASGNVASEDVVYLLHGLGMPTGIDLPALARTGRWLAQLLGRETGSKVGKALAAAA