Protein Info for Xcc-8004.2826.1 in Xanthomonas campestris pv. campestris strain 8004

Annotation: diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 696 transmembrane" amino acids 6 to 28 (23 residues), see Phobius details amino acids 39 to 63 (25 residues), see Phobius details amino acids 75 to 95 (21 residues), see Phobius details amino acids 107 to 127 (21 residues), see Phobius details amino acids 139 to 160 (22 residues), see Phobius details amino acids 171 to 190 (20 residues), see Phobius details amino acids 214 to 237 (24 residues), see Phobius details PF03707: MHYT" amino acids 51 to 108 (58 residues), 81.1 bits, see alignment 6.7e-27 amino acids 114 to 167 (54 residues), 68.3 bits, see alignment 6.7e-23 amino acids 180 to 240 (61 residues), 32.1 bits, see alignment 1.3e-11 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 262 to 422 (161 residues), 125.8 bits, see alignment E=7.1e-41 PF00990: GGDEF" amino acids 263 to 419 (157 residues), 144.7 bits, see alignment E=3.4e-46 PF00563: EAL" amino acids 439 to 674 (236 residues), 264 bits, see alignment E=1.6e-82

Best Hits

Swiss-Prot: 58% identical to Y1727_PSEAE: Uncharacterized signaling protein PA1727 (PA1727) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: None (inferred from 100% identity to xcc:XCC1911)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H2X9L1 at UniProt or InterPro

Protein Sequence (696 amino acids)

>Xcc-8004.2826.1 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) (Xanthomonas campestris pv. campestris strain 8004)
VLGTYNLSLVLLSLAVAVLASYTALHLAARMTASRGGIAAAWLVGGAIAMGFGIWSMHFV
GMLAFQLPIPLGYDLALTAYSMLVAILASALALWLTSRADLPWRRLSLGALLMGLGIALM
HYMGMAAMRMDPEITYDPLLFAVSVAIAIGASAAGLWIAFQLRHDGRRYSLRVVAAMIMG
VAIVGMHYTGMAAAQFAPGSICGAAGIGAQLPLSWLASVVAAVTLGLLGLALVISVLSRR
FQQRTDVLAQSLAQANQELVLAALHDPLTRLPNRVLLHEHVLQSIERGQRDGQRFAVMLI
DLDGFKAVNDGYGHQLGDQLLIAVAQRLGAHRRAHGSLARLGADEFVLVADIADPEDAAA
IAGHLVQALALPFLVGDHELRLSSSVGIALYPEDAGSEHQLMTHADAAMGHAKQAGRNRY
SFFDRSMTGTTRERLQLLQDLPRALELGQFALHYQPKYCAEDGRPLGAEALIRWLHPERG
MVPPDSFIPLAERSGMIGPLGKWVLEEACRQMRAWRDAGHGDWRVAVNLSATQLASPSLP
AEVAATLAAHAIAPGQLTLEITETMAMRDADACLRTLGQLTDLGVRIAIDDFGTGYSNLL
YLRKLPAHELKIDRSFVQAMDSGPEDIAIVAAVVALAHTMRLQVVAEGVETPAQRNTLER
LGCDQLQGYLLGRPMEPDRFIALVVAQRDGERRRAS