Protein Info for Xcc-8004.208.1 in Xanthomonas campestris pv. campestris strain 8004
Annotation: predicted 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01808, ribose 5-phosphate isomerase B [EC: 5.3.1.6] (inferred from 100% identity to xcb:XC_0162)MetaCyc: 51% identical to 5-dehydro-4-deoxy-D-glucuronate isomerase monomer (Streptococcus agalactiae NEM316)
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase. [EC: 5.3.1.17]
Predicted SEED Role
"predicted 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17)" (EC 5.3.1.17)
MetaCyc Pathways
- superpathway of glucose and xylose degradation (16/17 steps found)
- pentose phosphate pathway (8/8 steps found)
- pentose phosphate pathway (non-oxidative branch) I (5/5 steps found)
- formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
- Bifidobacterium shunt (12/15 steps found)
- Rubisco shunt (8/10 steps found)
- pentose phosphate pathway (non-oxidative branch) II (5/6 steps found)
- formaldehyde assimilation II (assimilatory RuMP Cycle) (7/9 steps found)
- 4-deoxy-L-threo-hex-4-enopyranuronate degradation (4/5 steps found)
- Calvin-Benson-Bassham cycle (9/13 steps found)
- ethene biosynthesis V (engineered) (17/25 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (18/27 steps found)
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (17/26 steps found)
- oxygenic photosynthesis (10/17 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (15/31 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Carbon fixation in photosynthetic organisms
- Pentose and glucuronate interconversions
- Pentose phosphate pathway
Isozymes
Compare fitness of predicted isozymes for: 5.3.1.17, 5.3.1.6
Use Curated BLAST to search for 5.3.1.17 or 5.3.1.6
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0H2X2N0 at UniProt or InterPro
Protein Sequence (218 amino acids)
>Xcc-8004.208.1 predicted 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17) (Xanthomonas campestris pv. campestris strain 8004) MKIALMNEFSQAAKNPVILQQLNDVASEQGHDVFNVGMDGDNDHRLTYIHLGIVASLLLN AKAVDFVVAGCGTGQGAMMSLNAHPGVFCGYCIEPTDAYLFAQVNNGNALSLAFAKGYGW GAEINVRYIFEKAFSGERGLGYPAERRESQAANAGILTQVKQATAKSYLDGLRAIDPELI KQAIGGARFQQCFFDNAQDAEIRSFVAGLLGKSEAAAA