Protein Info for Xcc-8004.1128.1 in Xanthomonas campestris pv. campestris strain 8004
Annotation: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to GSA_XANCP: Glutamate-1-semialdehyde 2,1-aminomutase (hemL) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
KEGG orthology group: K01845, glutamate-1-semialdehyde 2,1-aminomutase [EC: 5.4.3.8] (inferred from 100% identity to xca:xccb100_0912)MetaCyc: 64% identical to glutamate-1-semialdehyde 2,1-aminomutase subunit (Salmonella enterica enterica serovar Typhimurium)
Glutamate-1-semialdehyde 2,1-aminomutase. [EC: 5.4.3.8]
Predicted SEED Role
"Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 5.4.3.8)
MetaCyc Pathways
- superpathway of heme b biosynthesis from glutamate (9/10 steps found)
- tetrapyrrole biosynthesis I (from glutamate) (6/6 steps found)
- adenosylcobalamin biosynthesis II (aerobic) (21/33 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (20/36 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 5.4.3.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q4UYA7 at UniProt or InterPro
Protein Sequence (429 amino acids)
>Xcc-8004.1128.1 Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) (Xanthomonas campestris pv. campestris strain 8004) MNHSRSHALFSQAQNLMPGGVNSPVRAFKSVGGEPFFVARADGAYLFDVDGNRYIDYVGS WGPMIAGHNHPAVREAVERAIRDGLSFGAPCEAEVTMAETITRLVPSCEMVRMVNSGTEA TLSAIRLARGATGRNRIVKFEGCYHGHGDSFLVKAGSGMLTLGVPTSPGVPAGLSELTAT LSFNDFEGATALFDEIGAEVAAVIIEPVVGNANCIPPQAGYLQHLRTLCTRHGALLIFDE VMTGFRVALGGAQAHYGVTPDLTTFGKIIGGGMPVGAYGGGRDLMEQISPAGPIYQAGTL SGNPVAMAAGLAMLQLVQEPGFHARLSETTSLLCEGLEDAARAAGVAVTTNQVGGMFGLF FTDQIVENYAQATACDVTTFNRFFHAMLQQGVYLAPSAYEAGFVSSAHDEAVIEATLAAA REAFADVMR